Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities

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Abstract

Background:

People with multiple sclerosis (MS) have identified “wellness” and associated behaviors as a high priority based on “social media listening” undertaken by the National MS Society (i.e. the Society).

Objective:

The Society recently convened a group that consisted of researchers with experience in MS and wellness-related research, Society staff members, and an individual with MS for developing recommendations regarding a wellness research agenda.

Method:

The members of the group engaged in focal reviews and discussions involving the state of science within three approaches for promoting wellness in MS, namely diet, exercise, and emotional wellness.

Results:

That process informed a group-mediated activity for developing and prioritizing research goals for wellness in MS. This served as a background for articulating the mission and objectives of the Society’s Wellness Research Working Group.

Conclusion:

The primary mission of the Wellness Research Working Group is the provision of scientific evidence supporting the application of lifestyle, behavioral, and psychosocial approaches for promoting optimal health of mind, body, and spirit (i.e. wellness) in people with MS as well as managing the disease and its consequences.

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Most cited references 22

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Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development.

Amy Latimer-Cheung, Lara Pilutti, Audrey L Hicks … (2013)

To conduct a systematic review of evidence surrounding the effects of exercise training on physical fitness, mobility, fatigue, and health-related quality of life in adults with multiple sclerosis (MS). The databases included EMBASE, 1980 to 2011 (wk 12); Ovid MEDLINE and Ovid OLDMEDLINE, 1947 to March (wk 3) 2011; PsycINFO, 1967 to March (wk 4) 2011; CINAHL all-inclusive; SPORTDiscus all-inclusive; Cochrane Library all-inclusive; and Physiotherapy Evidence Database all-inclusive. The review was limited to English-language studies (published before December 2011) of people with MS that evaluated the effects of exercise training on outcomes of physical fitness, mobility, fatigue, and/or health-related quality of life. One research assistant extracted data and rated study quality. A second research assistant verified the extraction and quality assessment. From the 4362 studies identified, 54 studies were included in the review. The extracted data were analyzed using a descriptive approach. There was strong evidence that exercise performed 2 times per week at a moderate intensity increases aerobic capacity and muscular strength. The evidence was not consistent regarding the effects of exercise training on other outcomes. Among those with mild to moderate disability from MS, there is sufficient evidence that exercise training is effective for improving both aerobic capacity and muscular strength. Exercise may improve mobility, fatigue, and health-related quality of life. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

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The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review

Stephen C Reingold, Jeffrey Cohen, Olaf Stuve … (2015)

Background: Psychiatric comorbidity is associated with lower quality of life, more fatigue, and reduced adherence to disease-modifying therapy in multiple sclerosis (MS). Objectives: The objectives of this review are to estimate the incidence and prevalence of selected comorbid psychiatric disorders in MS and evaluate the quality of included studies. Methods: We searched the PubMed, PsychInfo, SCOPUS, and Web of Knowledge databases and reference lists of retrieved articles. Abstracts were screened for relevance by two independent reviewers, followed by full-text review. Data were abstracted by one reviewer, and verified by a second reviewer. Study quality was evaluated using a standardized tool. For population-based studies we assessed heterogeneity quantitatively using the I 2 statistic, and conducted meta-analyses. Results: We included 118 studies in this review. Among population-based studies, the prevalence of anxiety was 21.9% (95% CI: 8.76%–35.0%), while it was 14.8% for alcohol abuse, 5.83% for bipolar disorder, 23.7% (95% CI: 17.4%–30.0%) for depression, 2.5% for substance abuse, and 4.3% (95% CI: 0%–10.3%) for psychosis. Conclusion: This review confirms that psychiatric comorbidity, particularly depression and anxiety, is common in MS. However, the incidence of psychiatric comorbidity remains understudied. Future comparisons across studies would be enhanced by developing a consistent approach to measuring psychiatric comorbidity, and reporting of age-, sex-, and ethnicity-specific estimates.

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Effects of exercise training on fatigue in multiple sclerosis: a meta-analysis.

Lara Pilutti, Tina Greenlee, Robert W. Motl … (2015)

To provide a quantitative synthesis of randomized controlled trials examining the effect of exercise training on symptomatic fatigue in persons with multiple sclerosis (MS). Electronic databases (Web of Science, PubMed, PsycInfo, and Google Scholar) were searched for articles published between 1960 and October 2012 by using the key words "fatigue," OR "tiredness," OR "energy," OR "mood," OR "lassitude," AND "exercise," OR "physical activity," OR "rehabilitation," OR "fitness" WITH "multiple sclerosis." The initial search resulted in 311 articles, of which 74 were reviewed in detail and 17 met the inclusion criteria and provided enough data to compute effect sizes (ESs; Cohen d). The meta-analysis was conducted using a meta-analysis software program, and a random-effects model was used to calculate the overall ES, expressed as Hedge g. The weighted mean ES from 17 randomized controlled trials with 568 participants with MS was 0.45 (standard error = 0.12, 95% confidence interval = 0.22-0.68, z = 3.88, p ≤ .001). The weighted mean ES was slightly heterogeneous (Q = 29.9, df = 16, p = .019). The cumulative evidence supports that exercise training is associated with a significant small reduction in fatigue among persons with MS.

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Author and article information

Contributors

Robert W Motl

Ellen M Mowry

Dawn M Ehde

Nicholas G LaRocca

Kathy E Smith

Kathleen Costello

Lynne Shinto

Alexander V Ng

Amy B Sullivan

Barbara Giesser

Kevin K McCully

Bo Fernhall

Malachy Bishop

Matthew Plow

Patrizia Casaccia

Nancy D Chiaravalloti

Journal

Journal ID (nlm-ta): Mult Scler

Journal ID (iso-abbrev): Mult. Scler

Journal ID (publisher-id): MSJ

Journal ID (hwp): spmsj

Title: Multiple Sclerosis (Houndmills, Basingstoke, England)

Publisher: SAGE Publications (Sage UK: London, England )

ISSN (Print): 1352-4585

ISSN (Electronic): 1477-0970

Publication date (Electronic): 12 January 2017

Publication date (Print): March 2018

Volume: 24

Issue: 3

Pages: 262-267

Affiliations

[1-1352458516687404]Department of Physical Therapy, The University of Alabama at Birmingham, Birmingham, AL, USA

[2-1352458516687404]Department of Epidemiology and Department of Neurology, Johns Hopkins University, Baltimore, MD, USA

[3-1352458516687404]Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA

[4-1352458516687404]National Multiple Sclerosis Society, New York, NY, USA

[5-1352458516687404]National Multiple Sclerosis Society, New York, NY, USA

[6-1352458516687404]National Multiple Sclerosis Society, New York, NY, USA

[7-1352458516687404]Department of Neurology, Oregon Health & Science University, Portland, OR, USA

[8-1352458516687404]Exercise Science Program, Physical Therapy Department, Marquette University, Milwaukee, WI, USA

[9-1352458516687404]Mellen Center for MS, Cleveland Clinic Foundation, Cleveland, OH, USA

[10-1352458516687404]Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA

[11-1352458516687404]Department of Kinesiology, University of Georgia, Athens, GA, USA

[12-1352458516687404]College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA

[13-1352458516687404]Early Childhood, Special Education, and Rehabilitation Counseling, University of Kentucky, Lexington, KY, USA

[14-1352458516687404]Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA

[15-1352458516687404]Icahn School of Medicine at Mount Sinai and Advanced Research Science Center, City University at New York, New York, NY, USA

[16-1352458516687404]Kessler Foundation, East Hanover, NJ, USA

Author notes

[*]Department of Physical Therapy, The University of Alabama at Birmingham, 1705 University Blvd, SHPB 336, Birmingham, AL 35233-1212, USA. robmotl@ 123456uab.edu

Article

Publisher ID: 10.1177_1352458516687404

DOI: 10.1177/1352458516687404

PMC ID: 5494005

PubMed ID: 28080254

SO-VID: d882d0a1-82af-43ae-9203-6f17eb3da8c5

License:

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

History

Date received : 20 October 2016

Date revision received : 8 December 2016

Date accepted : 9 December 2016

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Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities

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Abstract

Background:

Objective:

Method:

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Conclusion:

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Most cited references 22

Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development.

The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review

Effects of exercise training on fatigue in multiple sclerosis: a meta-analysis.

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