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Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction.
Florian Leuschner
1 ,
Peter Panizzi ,
Isabel Chico-Calero ,
Won Woo Lee ,
Takuya Ueno ,
Virna Cortez-Retamozo ,
Peter Waterman ,
Rostic Gorbatov ,
Brett Marinelli ,
Yoshiko Iwamoto ,
Aleksey Chudnovskiy ,
Jose-Luiz Figueiredo ,
David E Sosnovik ,
Mikael J Pittet ,
Filip K Swirski ,
Ralph Weissleder ,
Matthias Nahrendorf
Nov 26 2010
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Abstract
Monocytes recruited to ischemic myocardium originate from a reservoir in the spleen, and the release from their splenic niche relies on angiotensin (Ang) II signaling.