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      Pain catastrophizing and associated factors in preoperative total knee arthroplasty in Lanzhou, China: a cross-sectional study

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          Abstract

          Background

          Pain catastrophizing in preoperative total knee arthroplasty (TKA) patients is associated with several poorly characterised factors in the literature. This study investigated the current state and associated factors of preoperative pain catastrophizing in patients undergoing TKA.

          Methods

          This descriptive cross-sectional study was conducted at the orthopedics ward of two tertiary hospitals in Lanzhou, China. Pain catastrophizing was measured using the Chinese versions of the Pain Catastrophizing Scale, Short Form-36 (physical function domain), Numerical Rating Scale, Oxford Knee Score, Hospital Anxiety and Depression Scale, and Life Orientation Test-Revised.

          Results

          The study included 360 participants. Preoperative TKA pain catastrophizing in all patients was high, with a mean score of 24.92 (SD: 12.38). The stepwise multiple linear regression analysis revealed anxiety ( β = 0.548, P < 0.01), education level ( β =  − 0.179, P < 0.01), physical function ( β =  − 0.156, P < 0.01), and pain intensity during activity ( β = 0.105, P = 0.015) as associated factors for pain catastrophizing, possibly explaining 51.2% of the total variation ( F = 95.149, P < 0.01).

          Conclusion

          Anxiety was the most relevant factor for pain catastrophizing in patients with preoperative TKA. Lower education levels, poor physical function, and stronger pain intensity during the activity were also associated with pain catastrophizing.

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          Most cited references42

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          The hospital anxiety and depression scale.

          A self-assessment scale has been developed and found to be a reliable instrument for detecting states of depression and anxiety in the setting of an hospital medical outpatient clinic. The anxiety and depressive subscales are also valid measures of severity of the emotional disorder. It is suggested that the introduction of the scales into general hospital practice would facilitate the large task of detection and management of emotional disorder in patients under investigation and treatment in medical and surgical departments.
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            Pain catastrophizing: a critical review.

            Pain catastrophizing is conceptualized as a negative cognitive-affective response to anticipated or actual pain and has been associated with a number of important pain-related outcomes. In the present review, we first focus our efforts on the conceptualization of pain catastrophizing, highlighting its conceptual history and potential problem areas. We then focus our discussion on a number of theoretical mechanisms of action: appraisal theory, attention bias/information processing, communal coping, CNS pain processing mechanisms, psychophysiological pathways and neural pathways. We then offer evidence to suggest that pain catastrophizing represents an important process factor in pain treatment. We conclude by offering what we believe represents an integrated heuristic model for use by researchers over the next 5 years; a model we believe will advance the field most expediently.
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              What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients

              Introduction Symptoms of osteoarthritis are managed in the community, but if pharmacological and conservative treatments provide inadequate relief, then total joint replacement is commonly performed. In England and Wales during the year ending March 2010, there were 71 021 primary total hip and 79 263 primary total knee replacement operations recorded in the National Joint Registry.1 In the USA in 2006, the estimated numbers of hospital discharges after total hip or knee replacement procedures were 231 000 and 542 000, respectively,2 with demand predicted to increase substantially.3 Total hip or knee replacement is highly successful when judged by prosthesis-related outcomes, such as the radiographic appearance of the prosthesis,4 implant survival5 or surgeon-assessed outcome.6 Nevertheless, many people continue to experience significant pain and functional problems after total joint replacement. Woolhead and colleagues7 conducted in-depth interviews with 10 patients 6-months after their total knee replacement. Although patients considered their joint replacement successful, eight of the 10 patients still experienced pain and immobility. In a European collaborative study of 1327 patients with total hip replacement, Judge and colleagues8 applied three recognised criteria for general symptomatic improvement with symptom severity based on pain, stiffness and physical function according to the WOMAC osteoarthritis index.9 The different criteria suggested that between 14% and 36% of patients did not improve or were worse 12 months after surgery. Pain is the most important factor in the decision to recommend total joint replacement.10 Furthermore, patient-reported pain is now widely assessed using disease-specific outcome measures. In the USA, the importance of patient-reported outcomes in assessing quality of care is recognised,11 and in England, following the report of Lord Darzi,12 information is routinely collected after elective surgery.13 Reporting of pain outcomes in the orthopaedic literature frequently emphasises improvement in mean scores. An example of this is the study of Bachmeier and colleagues14 where the improvement of mean WOMAC pain scores at 3, 6, 9 and 12 months after hip or knee replacement is clearly demonstrated. However, at all time points, the mean pain score has an associated SD implying that a proportion of patients still reported pain. To advise both patients and their healthcare professionals, it is important to have a clear understanding of the frequency and extent of pain following total hip or knee replacement. We have used systematic review methods to identify studies reporting the proportion of people with significant long-term pain after total hip or knee replacement. We aimed to identify studies in populations representative of contemporary clinical practice. Some information on all patients in cohorts is required as patients lost to follow-up may have experienced poorer or at least similar outcomes to those followed up.15–18 Methods We used systematic review methods in accordance with the MOOSE proposal for reporting systematic reviews and meta-analyses of observational studies.19 A MOOSE checklist is shown in online appendix 1. Data sources and searches MEDLINE and EMBASE databases were searched from inception to 31 January 2011. A general search was performed to identify quantitative research in primary total hip or knee replacement. The MEDLINE search strategy is shown in online appendix 2. Search terms related to hip or knee replacement and studies with an epidemiological design including prospective and longitudinal studies. No language restrictions were applied. Within titles, abstracts and keywords of articles identified, we searched for text words relating to osteoarthritis and disease-specific patient-centred pain outcome measures used in osteoarthritis and joint replacement. Specifically these were Western Ontario and McMaster Universities Arthritis Index (WOMAC), Arthritis Impact (AIMS), Lequesne, Oxford hip or Oxford knee score, Hip Osteoarthritis Outcome Score (HOOS) or Knee Osteoarthritis Outcome Score (KOOS), pain visual analogue scales (VAS) and self-appraisal. Outcomes not considered patient centred were Harris Hip, American Knee Society and Bristol Knee Scores. We did not include generic health measures including the Health Assessment Questionnaire, EuroQol, London Handicap Scale, Medical Outcomes Study Short Form-36 (SF-36), Disease Repercussion Profile, Sickness Impact Profile and WHOQol-BREF. We also checked citations of key articles in ISI Web of Science and reference lists. Studies reported only as abstracts were excluded. References were managed in an Endnote X3 database. Study selection We included prospective studies of consecutive unselected patients representative of the primary total hip or knee replacement population. Studies reporting a specific implant or component were eligible if the population studied was not clearly selected, that is, the group was likely to be representative of the total joint replacement population. Study designs excluded were cross-sectional and retrospective studies, randomised controlled trials and evaluations of specific technologies. Randomised controlled trials and many evaluations of new technologies comprise selected populations, and furthermore, it is outside the scope of this review to assess whether these reflect best clinical practice. We made an a priori decision to limit follow-up to between 3 months and 5 years. In evaluating the effectiveness of primary total hip or knee replacement in reducing pain from osteoarthritis, we are concerned with outcomes when recovery can be considered maximal14 and not later issues of joint loosening and revision.20 Study titles, abstracts and, where necessary, full articles were checked independently for eligibility by two researchers experienced in systematic reviews (ADB) and rheumatology (PD). Disagreements were resolved by discussion. Validity of the database was confirmed by checking against reference lists provided by local experienced researchers in orthopaedic outcomes. While we recognise that studies may include patients with other joint replacement surgery, we excluded studies specifically describing outcomes of revision operations and partial joint replacements (eg, unicompartmental or patellofemoral knee replacement and hip resurfacing). Data extraction The pain measure relating to the operated hip or knee was considered in the review. No attempt was made to contact authors of studies who did not have appropriate data. In the previous reviews we have conducted only a minority of authors contacted have provided additional data for analyses. Although contact with authors is a well-recognised approach in systematic reviews,21 a survey of review authors indicated that many systematic reviewers do not do so because of poor response rates and variability in the quality of information collected this way.22 Authors of studies with appropriate data but with specific missing information were contacted. Data from eligible articles were recorded on an Excel spreadsheet by one reviewer (ADB) and checked against original articles by a second (VW). Data were extracted on indication (all or majority of patients with osteoarthritis), pain outcome, baseline dates, country, study design, how group selected, age, number of patients recruited, number who died and the number lost to follow-up. We recorded the number of people at follow-up with no pain or mild pain, moderate or severe pain (or with little improvement in pain from preoperative), revision or dislocations or deep infection and contralateral or other joint replacement or treatment for fracture. Data synthesis and analysis As studies reported different pain measures, we summarised pain outcomes in a way that was applicable to all measures. The proportions of people with different severities of pain were summarised as ‘favourable’, ‘unfavourable’ or ‘uncertain’ outcomes. Favourable outcome includes people with no pain or mild pain at follow-up, while unfavourable outcome includes those with moderate-to-severe pain or for whom surgery had not relieved pain. The uncertain outcome includes all patients for whom we cannot be sure of their pain levels at follow-up. These include patients who died, had revision surgery, contralateral surgery or dislocation and were not followed up with questionnaires and those lost to follow-up. We also included as uncertain those patients with a degree of reported pain, which we could not classify as a favourable or unfavourable outcome. Quality assessment Only studies with unselected patients and complete reporting of losses to follow-up were included. To describe the quality of studies, we used the features of the Cochrane risk of bias table applicable to longitudinal studies.21 Specifically, these were blind outcome assessment (self-completed patient-reported outcome measure), incompleteness of outcome data collection (losses to follow-up low 20%) and other sources of bias (representativeness of study population). Results The review process is summarised in figure 1. Searches identified 1308 studies reporting patient-centred outcomes in patients with osteoarthritis. Of these, 115 studies included data on patient-centred pain outcomes in representative population samples studied prospectively for between 3 months and 5 years. Fourteen articles describing 17 cohorts (6 in hip and 11 in knee patients) presented results classifiable as proportions of people with different extents of pain at follow-up. The main reasons for exclusion at this stage were lack of a pain outcome separate from an overall outcome score or the presentation of results as means only. Figure 1 Systematic review flow diagram. Patient and study characteristics and outcomes are shown in table 1. The proportions of people with different pain outcomes are summarised in figure 2. Table 1 Studies of total hip or knee replacement reporting proportion of patients with pain at follow-up Author, country date of baseline Indication, population, age Follow-up, study design, losses to follow-up Pain outcome measure Number of patients with Favourable outcome Uncertain outcome Unfavourable outcome Hip replacement  Nikolajson et al,23 Denmark, 2003 Primary THR, degenerative hip arthritis N=1231 questionnaire follow-up of consecutive patients Mean age 71.6 years (SD 8.7) 12–18-month follow-up Joint registry 5.9% lost to follow-up Authors' own scale of presence of hip pain and impact on daily life 754 (hip pain not present) 4 died 117 lost to follow-up 62 bilateral or further operation 167 hip pain still present with no/mild impact on daily life 127 (pain with moderate, severe or very severe impact on daily life)  Jones et al,24 Canada, 1995–1997 Primary THR, 94% OA N=242 consecutive patients (includes estimated lost to follow-up based on equal proportions hip/knee lost) Mean age 68.2 years (SD 11.1) 6-month follow-up Prospective 5.8% lost to follow-up or died (Losses to follow-up estimated proportionately as not reported for hip and knee separately) WOMAC pain Losses to follow-up estimated proportionately as not reported for hip and knee separately 208 (no pain/mild pain defined as more than a 10-point gain on the 100-point WOMAC pain dimension) 14 lost to follow-up (estimated) 20 (moderate/severe pain defined as a gain of 30 on a 100-mm pain VAS) 34 (none or mild pain) 1 died 6 lost to follow-up 1 infection 9 (moderate or severe pain)  Czurda et al,35 Austria, 2003–2005 Primary TKR, OA N=411 consecutive patients with computer-assisted or conventional surgery with at least 18-month follow-up Mean age 75–76 years (range 45–96) Mean 26-month follow-up (range 18–42) 13.4% lost to follow-up WOMAC pain 273 (no report of painful knees—no moderate or worse response in any WOMAC pain dimension) 2 died 55 lost to follow-up 24 infection, trauma, reoperation, poor general condition 57 (painful knees—moderate or worse response in any WOMAC pain dimension)  Wylde et al,28 UK, 2004–2006 TKR, majority OA N=1394 consecutive patients Median age 73 (range 28–96) Median 41-month follow-up (range 34–49) Prospective with postal follow-up 45.3% lost to follow-up WOMAC pain 433 (no pain for the past 3 months or mild persistent pain in replaced hip) 62 died 4 revision 696 lost to follow-up 199 (moderate or severe persistent pain for 3 months in replaced hip, WOMAC 0–75/100)  Brander et al,36 USA, 1998–2000 Primary TKR, 94% OA N=116 consecutive patients (1 surgeon) Mean age 66 years (SD 10.5, range 36–85) 12-month follow-up Prospective 0% lost to follow-up VAS pain 98 (no significant pain, VAS score ≤40) 1 died 2 revision or dislocation 15 (significant pain, VAS score >40) Studies ordered within hip and knee replacement groups by decreasing representativeness (multiple compared with single centre) and by increasing losses to follow-up. KOOS, Knee Osteoarthritis Outcome Score; THR, total hip replacement; TKR, total knee replacement; OA, osteoarthritis; VAS, visual analogue scales; WOMAC, Western Ontario and McMaster Universities Arthritis Index. Figure 2 Studies of hip or knee replacement reporting proportion of patients with pain at follow-up. Preceding study author: H (hip), K (knee) and months (follow-up). Studies ordered within hip and knee replacement groups by decreasing representativeness (multiple compared with single centre) and by increasing losses to follow-up. Total hip replacement Systematic searches identified six studies from Canada, Denmark, Spain, Sweden, UK and USA including a total of 13 031 patients. Pain outcome measures were based on the WOMAC pain scale or authors' own methods. The measures used and the definition of unfavourable pain outcome are summarised for each study in online appendix 3. Study quality Issues relating to study quality are summarised in online appendix 4. Studies described data collected prospectively in consecutive patients with primary total hip replacement. One study was in patients recruited from a national joint registry.23 Two studies were in multiple centres24 25 and three were studies in single centres.26–28 Cohorts were generally similar with regard to patient age (range of means or medians 65.0–73.0 years) and sex (range of percentage female 48.3%–63%), and the indication was osteoarthritis in 87% of patients or more when specified. One national registry study from Denmark included only patients treated with a postero-lateral surgical approach.23 However, the posterior or lateral approach was used in 99% of patients according to another publication from the Danish Hip Registry.37 Otherwise, no inclusion or exclusion criteria suggested that the patients' studies would not have been representative of the overall total hip replacement population. All studies used self-completed patient reported outcome measures. Losses to follow-up ranged from 5.8% to 47.6%. We considered two markers of better representativeness as indicators of study quality: studies with multiple compared with single centres and by lower losses to follow-up. WOMAC pain Jones and colleagues24 followed up a cohort of 242 consecutive patients receiving total hip replacement in a health region 6 months after total hip replacement. Patients undergoing hemiarthroplasty, revisions and emergency surgery were excluded. Losses to follow-up were low at under 5.8%. Results were presented combined with a total knee replacement cohort, and with the consent of the author, we assumed that equal proportions of hip and knee patients were followed up. The WOMAC outcome used to define a poor pain outcome was an improvement of 30 on a 100-mm VAS pain scale, was reported in 17.6% of patients (uncertain 15.7%). In the study of Brander and colleagues,36 116 consecutive patients treated with primary total knee replacement by a single surgeon were followed prospectively for up to 12 months. Using a VAS scale, the authors identified significant knee pain (defined as a VAS score of >40) in 12.9% of patients (uncertain 2.6%). No patients were lost to follow-up. Overview Total hip replacement Overall, an unfavourable pain outcome was seen in at least 4.8% and up to 20.5% of patients after hip replacement (figure 2). However, these are likely to be underestimates as we do not have information on the outcomes in between 5.8% and 52.7% of patients. As indicators of studies with more representative populations, the three studies in multiple centres reported an unfavourable pain outcome relating to the operated hip in 8.3%, 10.3% and 16.3% of patients followed up. Studies with low losses to follow-up reported an unfavourable pain outcome in 8.3%, 10.3% and 20.5% of patients. Even considering studies with some degree of outcome consistency involving minimal clinically important differences, the range of unfavourable pain outcome was wide with at least 8.1% and up to 20.5% of patients affected. Applying the conservative assumption that an equal proportion of patients with missing data had an unfavourable pain outcome, we estimate that at least 7%–23% of patients experienced long-term pain after hip replacement. In three higher quality studies as judged by representativeness, this would reflect an unfavourable pain outcome in 9%, 13% and 20% of patients, and in three studies with low losses to follow-up in 9%, 13% and 23% of patients. Two studies with both indicators of best study quality suggested that 9%–13% of patients had an unfavourable pain outcome after total hip replacement. Total knee replacement After knee replacement, an unfavourable pain outcome was seen in at least 8.0% and up to 26.5% of patients (figure 2). Three studies followed up populations from multiple centres and unfavourable pain outcomes relating to the operated knee were reported in 16.8%, 18.5% and 25.1% of patients. In four studies with low losses to follow-up, an unfavourable pain outcome was reported in 8.0%, 12.9%, 16.2% and 18.5% of patients. Considering studies with some degree of outcome consistency, the range of unfavourable pain outcome was wide with at least 14.3% and up to 25.1% of patients affected. These are likely to be underestimates as we do not have outcome information on between 2.6% and 54.7% of patients. Assuming conservatively that the patients with missing data had similar pain outcomes, studies suggested that at least 10%–34% of patients experience long-term pain after knee replacement. Applying this assumption in the higher quality studies with potentially more representative populations, at least 19%, 20% and 31% of patients had an unfavourable pain outcome after total knee replacement. In four studies with low losses to follow-up, 10%, 13%, 17% and 20% of patients reported an unfavourable pain outcome at follow-up. In one study conducted in multiple centres with low losses to follow-up, 20% of patients reported an unfavourable pain outcome at follow-up. Discussion These data show that many people with a total hip or knee replacement complain of pain in the operated joint in the early years after surgery. This was particularly evident after total knee replacement. Although we have interpreted pain outcomes as favourable, unfavourable or uncertain, we do not believe that the data justify combination to provide summary values. In the studies identified in our review, several different outcome measures were reported, and in studies with similar outcomes, different methods of analysis were used. Without specific information on responsiveness and correlation between methods, an important additional source of heterogeneity may be introduced.38 Previous reviews have looked at functional and health-related quality of life after joint replacement. Kane and colleagues39 reported functional outcomes after total knee replacement in a literature review of 62 studies published between 1995 and 2003. They concluded that knee replacement leads to improved function as shown by large effect sizes in studies but that larger benefits were perceived by physicians than experienced by patients. Ethgen and colleagues40 identified 74 prospective cohort studies published between 1980 and 2003 that included quality of life outcomes. The authors highlighted the value of health-related quality of life data in improving management of patients undergoing hip or knee replacement. They concluded that total hip and knee arthroplasties were ‘quite effective’ in improving health-related quality of life dimensions. In a large European cohort, Judge and colleagues8 concluded that 14%–36% of patients had no symptomatic improvement 12 months after total hip replacement. The results we present are consistent with those reporting satisfaction as an outcome. For example, Bourne and colleagues41 reported satisfaction with pain relief in a study in knee replacement patients. Satisfaction with pain relief ranged from 72% for going up or downstairs to 85% for walking on a flat surface. In systematic reviews, publication bias is important in assessing the validity of the results. In this review, we identified 95 studies where the proportion of people with pain at follow-up could have been estimated by authors with access to original data. In previous reviews that we have conducted, replies to requests for additional data have been patchy and we chose not to pursue this approach. Nevertheless, we encourage study authors to perform and publish appropriate analyses of their data. Similarly, a wealth of patient-centred outcome data is now collected routinely and merits wide dissemination. The majority of studies included in our review reported outcomes of patients after total joint replacement. A few studies followed up patients listed for total joint replacement, and it is possible that these studies included patients who subsequently received other surgical treatments including unicompartmental knee replacement or hip resurfacing. In this review, we were unable to apply a standard definition of pain severity at follow-up and the need to improve assessment and measurement of musculoskeletal pain in the clinical setting is recognised.42 In the articles we included there were several interpretations of pain as an unfavourable outcome. These included lack of improvement in postoperative pain scores, pain at rest, persistent pain, night pain and lack of detectable clinical improvement. Although having a standard outcome has advantages, our more encompassing approach allows us to include studies from wide time periods and different countries with different favoured methods for outcome assessment. However, the different outcome measures and small number of studies precluded exploration of sources of heterogeneity relating to patient characteristics, surgical method, peri-operative care and rehabilitation. In the studies included in this review, the measures may not fully describe chronic postsurgical pain. Measures that focus on pain during specific activities may not reflect the intermittent and intense pain that has the greatest impact on quality of life.43 Another issue in considering pain as an outcome after replacement is that no account is made for the effect of analgesics and assistive aids on the reporting of pain. Self-reported analgesic use is high with 40% of men and 58% of women taking pain medications after knee replacement44 and 30% of patients taking analgesics daily after hip replacement because of pain in their replaced joint.23 We used disease-specific instruments focusing on the operated joint rather than generic measures of pain. In the replacement population, there are likely to be high levels of morbidity due to osteoarthritis and other conditions common in old age. Our data suggest that many hip and knee replacement patients are likely to be in pain at the time when recovery from surgery should be optimal. In a cohort of 194 patients following hip or knee replacement surgery, pain was seen to achieve its lowest level by 3 months after surgery.14 While acknowledging probable underestimates of the extent of pain after surgery reported in the literature, we should recognise the effectiveness of replacement for many. However, a significant proportion of people have painful joints despite surgery and strategies to improve outcomes merit research. Many determinants of long-term outcome after hip and knee replacement are described and interventions evaluated. Better general health, physical, emotional and social function, motivation and self-efficacy and lower levels of pain before surgery and during the rehabilitation period are associated with improved short- and medium-term outcomes.26 45–47 However, the evidence for benefit of presurgical and rehabilitation interventions is limited, particularly as few studies have been adequately powered or of sufficient duration.48–52 Another approach is the identification of patients before surgery who are at risk of a poor pain outcome. Kalkman and colleagues53 developed a multivariable model to predict short-term pain after surgical procedures. Use of a predictive model based on presurgical or postsurgical factors might allow targeting of additional pain management and rehabilitation to patients likely to benefit. In conclusion, persistent pain in a hip or knee joint that has been replaced is not uncommon. For patients to participate in decisions about their care, it is important that they are informed and aware of both the likely benefits of surgery and the possibility of a less favourable outcome. With this knowledge, they may contribute more fully to the replacement process including preparatory strategies and long-term rehabilitation. It is clear that the current move to a greater interest in patient-centred outcomes after replacement is necessary and that there is an urgent need to address the determinants of good and bad outcomes. Supplementary Material Supporting Statement Supporting Statement Supporting Statement Supporting Statement Author's manuscript Reviewer comments
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                Contributors
                18093188800@163.com
                douxm@lzu.edu.cn
                Journal
                BMC Musculoskelet Disord
                BMC Musculoskelet Disord
                BMC Musculoskeletal Disorders
                BioMed Central (London )
                1471-2474
                28 May 2022
                28 May 2022
                2022
                : 23
                : 507
                Affiliations
                [1 ]GRID grid.412643.6, ISNI 0000 0004 1757 2902, The First Clinical Medical College, Lanzhou University, ; Lanzhou, Gansu China
                [2 ]GRID grid.411294.b, ISNI 0000 0004 1798 9345, Oncology Surgery Department, , Lanzhou University Second Hospital, ; Lanzhou, China
                [3 ]GRID grid.417234.7, ISNI 0000 0004 1808 3203, Department of Spine Minimally Invasive Orthopedics, , Gansu Provincial Hospital of Traditional Chinese Medicine, ; Lanzhou, Gansu China
                [4 ]GRID grid.417234.7, ISNI 0000 0004 1808 3203, Department of Anesthesia and Surgery, , Gansu Provincial Hospital of Traditional Chinese Medicine, ; Lanzhou, Gansu China
                [5 ]GRID grid.417234.7, ISNI 0000 0004 1808 3203, Department of Emergency, , Gansu Provincial Hospital of Traditional Chinese Medicine, ; Lanzhou, Gansu China
                [6 ]GRID grid.418117.a, ISNI 0000 0004 1797 6990, Clinical college of Traditional Chinese Medicine, , Gansu university of Chinese medicine, ; No. 418, guazhou Road, Qilihe District, Lanzhou, 730000 Gansu Province China
                [7 ]GRID grid.418117.a, ISNI 0000 0004 1797 6990, The First Affiliated Hospital, , Gansu University of Traditional Chinese Medicine, ; Lanzhou, Gansu, China
                [8 ]GRID grid.411294.b, ISNI 0000 0004 1798 9345, Department of Nursing, , Lanzhou University Second Hospital, ; Lanzhou, China
                Article
                5435
                10.1186/s12891-022-05435-1
                9145464
                34980067
                d88fbde8-888a-4646-90b7-27850c2cbd46
                © The Author(s) 2022

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 12 October 2021
                : 11 April 2022
                Funding
                Funded by: the National Natural Science Foundation of China
                Award ID: 81760877
                Funded by: Gansu Province Science and Technology Planning Project (Major Project)21ZD4FA009
                Categories
                Research
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                © The Author(s) 2022

                Orthopedics
                pain catastrophizing,anxiety,pain,associated factors,total knee arthroplasty
                Orthopedics
                pain catastrophizing, anxiety, pain, associated factors, total knee arthroplasty

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