Edgar Ortiz-Brizuela , Marco Villanueva-Reza , María F. González-Lara , Karla M. Tamez-Torres , Carla M. Román-Montes , Bruno A. Díaz-Mejía , Esteban Pérez-García , Antonio Olivas-Martínez , Sandra Rajme-López , Bernardo A. Martinez-Guerra , Nereyda A. de León-Cividanes , Oscar A. Fernández-García , Lorena Guerrero-Torres , Lorena Torres-González , Fabián A. Carrera-Patiño , Ever A. Corral-Herrera , Aldo N. Hernández-Alemón , Maria de los Ángeles Tovar-Vargas , Yamile G. Serrano-Pinto , Cristian E. Espejo-Ortiz , María de la L. Morales-Ortega , Óscar A. Lozano-Cruz , José L. Cárdenas-Fragoso , José de J. Vidal-Mayo , Thierry Hernández-Gilsoul , Eduardo Rivero-Sigarroa , Guillermo Domínguez-Cherit , Luz E. Cervantes-Villar , Maria del P. Ramos-Cervantes , Violeta Ibarra-González , Juan J. Calva-Mercado , Juan G. Sierra-Madero , Álvaro López-Íñiguez , Eric Ochoa-Hein , Brenda E. Crabtree-Ramírez , Arturo Galindo-Fraga , María de L. Guerrero-Almeida , Guillermo M. Ruiz-Palacios , Alfonso Gulías-Herrero , José Sifuentes-Osornio , David Kershenobich-Stalnikowitz , Alfredo Ponce-de-León
ABSTRACT Background: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding of the pandemic. Objective: The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC). Methods: We conducted a prospective cohort, including consecutive patients with COVID-19 from February 26, 2020 to April 11, 2020. Results: We identified 309 patients (140 inpatients and 169 outpatients). The median age was 43 years (interquartile range, 33-54), 59.2% men, and 18.6% healthcare workers (12.3% from our center). The median body mass index (BMI) was 29.00 kg/m2 and 39.6% had obesity. Compared to outpatients, inpatients were older, had comorbidities, cough, and dyspnea more frequently. Twenty-nine (20.7%) inpatients required treatment in the IC unit (ICU). History of diabetes (type 1 or 2) and abdominal pain were more common in ICU patients compared to non-ICU patients. ICU patients had higher BMIs, higher respiratory rates, and lower room-air capillary oxygen saturations. ICU patients showed a more severe inflammatory response as assessed by white blood cell count, neutrophil and platelet count, C-reactive protein, ferritin, procalcitonin, and albumin levels. By the end of the study period, 65 inpatients had been discharged because of improvement, 70 continued hospitalized, and five had died. Conclusions: Patients with comorbidities, either middle-age obese or elderly complaining of fever, cough, or dyspnea, were more likely to be admitted. At admission, patients with diabetes, high BMI, and clinical or laboratory findings consistent with a severe inflammatory state were more likely to require IC.