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Abstract
There are several enzymes, acetylases and deacetylases, that can regulate transcription
by modifying the acetylation state of histones or other promoter-bound transcription
factors. Some of these enzymes are present in multisubunit complexes. Recent efforts
to understand the biological role of these enzymes reveals their involvement in cell-cycle
regulation and differentiation. Furthermore, accumulating evidence suggests that deregulation
of acetylase and deacetylase activity plays a causative role in the generation of
cancer.