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      Rememorando la contribución de Goldstein y Brown al estudio del metabolismo del colesterol: a un cuarto de siglo del Premio Nobel de Medicina Translated title: The contribution of Goldstein and Brown to the study of cholesterol metabolism

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          Translated abstract

          Background: In December 1985, the Nobel Prize of Medicine was awarded to Drs. Joseph L. Goldstein and Michael S. Brown for their fundamental scientific work on the regulation of cholesterol metabolism mediated by the low density lipoprotein receptor pathway. This article briefly reviews the academic and research accomplishments of Drs. Brown and Goldstein as a tribute to these physician-scientists for their well-deserved award and enormous contribution to biomedical science worldwide.

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          Most cited references70

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          Protein sensors for membrane sterols.

          Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
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            A receptor-mediated pathway for cholesterol homeostasis

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              Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL.

              Cholesterol biosynthesis is among the most intensely regulated processes in biology. Synthetic rates vary over hundreds of fold depending on the availability of an external source of cholesterol. Studies of this feedback regulatory process have a rich history. The field began 75 years ago when Rudolf Schoenheimer measured cholesterol balance in mice in a bottle. He found that cholesterol feeding led to decreased cholesterol synthesis, thereby introducing the general phenomenon by which end products of biosynthetic pathways inhibit their own synthesis. Recently, cholesterol feedback has been explained at a molecular level with the discovery of membrane-bound transcription factors called sterol regulatory element-binding proteins (SREBPs), and an appreciation of the sterol-sensing role of their partner, an escort protein called Scap. The key element in Scap is a hexapeptide sequence designated MELADL (rhymes with bottle). Thus, over 75 years, Schoenheimer's bottle led to Scap's MELADL. In addition to their basic importance in membrane biology, these studies have implications for the regulation of plasma cholesterol levels and consequently for the development of atherosclerotic plaques, myocardial infarctions, and strokes. In this article we review the major milestones in the cholesterol feedback story.
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                Author and article information

                Journal
                rmc
                Revista médica de Chile
                Rev. méd. Chile
                Sociedad Médica de Santiago (Santiago, , Chile )
                0034-9887
                August 2012
                : 140
                : 8
                : 1053-1059
                Affiliations
                [02] Santiago orgnamePontificia Universidad Católica orgdiv1Departamento de Gastroenterología orgdiv2Escuela de Medicina Chile arigotti@ 123456med.puc.cl
                [01] Santiago orgnamePontificia Universidad Católica orgdiv1Departamentos de Nutrición, Diabetes y Metabolismo orgdiv2Escuela de Medicina Chile
                Article
                S0034-98872012000800014 S0034-9887(12)14000814
                10.4067/S0034-98872012000800014
                23282781
                d8aea885-1372-42f0-8594-83f95e2c312b

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 09 January 2012
                : 19 January 2012
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 39, Pages: 7
                Product

                SciELO Chile

                Categories
                ARTICULOS DE REVISION

                Nobel prize,Receptors,Cholesterol,lipoprotein
                Nobel prize, Receptors, Cholesterol, lipoprotein

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