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      Quantitative comparison of contrast and imaging depth of ultrahigh-resolution optical coherence tomography images in 800–1700 nm wavelength region

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          Abstract

          We investigated the wavelength dependence of imaging depth and clearness of structure in ultrahigh-resolution optical coherence tomography over a wide wavelength range. We quantitatively compared the optical properties of samples using supercontinuum sources at five wavelengths, 800 nm, 1060 nm, 1300 nm, 1550 nm, and 1700 nm, with the same system architecture. For samples of industrially used homogeneous materials with low water absorption, the attenuation coefficients of the samples were fitted using Rayleigh scattering theory. We confirmed that the systems with the longer-wavelength sources had lower scattering coefficients and less dependence on the sample materials. For a biomedical sample, we observed wavelength dependence of the attenuation coefficient, which can be explained by absorption by water and hemoglobin.

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          Most cited references25

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          Optical coherence tomography.

          A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
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            Optical coherence tomography (OCT): a review

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              Optical Constants of Water in the 200-nm to 200-microm Wavelength Region.

              Extinction coefficients k(lambda) for water at 25 degrees C were determined through a broad spectral region by manually smoothing a point by point graph of k(lambda) vs wavelength lambda that was plotted for data obtained from a review of the scientific literature on the optical constants of water. Absorption bands representing k(lambda) were postulated where data were not available in the vacuum uv and soft x-ray regions. A subtractive Kramers-Kronig analysis of the combined postulated and smoothed portions of the k(lambda) spectrum provided the index of refraction n(lambda) for the spectral region 200 nm
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                Author and article information

                Journal
                Biomed Opt Express
                BOE
                Biomedical Optics Express
                Optical Society of America
                2156-7085
                11 January 2012
                01 February 2012
                11 January 2012
                : 3
                : 2
                : 282-294
                Affiliations
                [1]Dept. of Electrical Engineering and Computer Science, Nagoya University, Nagoya, 464-8603, Japan
                Author notes
                Article
                157452
                10.1364/BOE.3.000282
                3269845
                22312581
                d8c10775-0e1e-41ad-824b-201c82ea69d7
                ©2012 Optical Society of America

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.

                History
                : 1 November 2011
                : 6 January 2012
                : 6 January 2012
                Categories
                Optical Coherence Tomography
                Custom metadata
                True
                0

                Vision sciences
                (110.4500) optical coherence tomography,(170.3880) medical and biological imaging

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