Cytotoxic steroidal saponins from Trillium kamtschaticum.

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Abstract

Eight new steroidal saponins, trillikamtosides K-R (1-8), along with three known analogues, were isolated from the whole plants of Trillium kamtschaticum. Their structures were unambiguously established by interpretation of spectroscopic data (MS and NMR) and chemical methods. Compound 1 had a rare aglycone featuring a skeleton of 16-oxaandrost-5-en-3-ol-17-one, which was reported for the first time. The isolated saponins were tested for cytotoxicities against HCT116 cells, and trillikamtoside R (8) was found to show the most cytotoxic effect with an IC50 value of 4.92μM.

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Journal

Journal ID (iso-abbrev): Bioorg. Med. Chem. Lett.

Title: Bioorganic & medicinal chemistry letters

Publisher: Elsevier BV

ISSN (Electronic): 1464-3405

ISSN (Print): 0960-894X

Publication date (Electronic): Jun 01 2017

Volume: 27

Issue: 11

Affiliations

[1 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.

[2 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

[3 ] Key Laboratory of Plant Biodiversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.

[4 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China. Electronic address: haiyangliu@mail.kib.ac.cn.

Article

Publisher Item ID: S0960-894X(17)30432-8

DOI: 10.1016/j.bmcl.2017.04.057

PubMed ID: 28454671

SO-VID: d8c84475-6075-4eb6-a29b-6280be3ce55c

History

Keywords: Steroidal saponins,Trillium kamtschaticum,Cytotoxicity,Liliaceae

Data availability:

Keywords: Steroidal saponins, Trillium kamtschaticum, Cytotoxicity, Liliaceae

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