Biochemical Determinations in a Recently Investigated Case of McArdle’s Disease

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Our study includes assays of the serum activities of ALD, CPK and GOT and GPT transaminase in a patient with McArdle’s disease. Muscle glycolysis has been investigated and the glycogen concentration and phosphorylase activity determined biochemically in the muscle biopsy. Our results point to three major biochemical features which are indicative of McArdle’s disease: in the blood, the failure of venous lactic acid to rise after ischaemic exercise, and in the muscle the increase of glycogen concentration and the lack of phosphorylase activity.

Related collections

Author and article information

Journal

Journal ID (publisher-id): ENE

Journal ID (nlm-ta): Eur Neurol

Journal ID (doi): 10.1159/issn.0014-3022

Title: European Neurology

Publisher: S. Karger AG

ISSN (Print): 0014-3022

ISSN (Electronic): 1421-9913

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 23 January 2008

Volume: 11

Issue: 1

Pages: 58-68

Affiliations

Institute of Neurology and Psychiatry (Dir.: Prof. A. Kreindler), Academy of Medical Sciences, Bucharest

Article

Publisher ID: 114306 Other ID: Eur Neurol 1974;11:58–68

DOI: 10.1159/000114306

PubMed ID: 4524323

SO-VID: d8cb2573-4821-453d-bf54-56705e6ce782

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 26 May 1973

Date accepted : 21 June 1973

Page count

Pages: 11

Comments

Comment on this article

scite_

Call for Papers: Sex and Gender in Neurodegenerative Diseases

Submit here before September 30, 2024