0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Quantitative, noninvasive assessment of intra‐ and extraocular perfusion by contrast‐enhanced ultrasonography and its clinical applicability in healthy dogs

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Objective

          To assess quantitative perfusion of intra‐ and extraocular regions of interest (ROIs) in conscious, healthy dogs utilizing contrast‐enhanced ultrasonography (CEUS); to compare varying enhancement with the first and second bolus injection and in the right and left eye; and to determine the most appropriate examination time.

          Procedures

          Gray scale ultrasonography and contrast harmonic imaging using sulfur hexafluoride were performed randomly assigned in both eyes in 10 university‐owned beagles. Perfusion parameters including slope time, time to peak (TTP), peak intensity (PI), and area under the curve (AUC) were measured at individually drawn ROIs (retrobulbar cone = ROI 1, choroid‐retina complex = ROI 2, medial = ROI 3, and lateral anterior uvea = ROI 4).

          Results

          Time‐intensity curve parameters revealed no significant differences in eyes examined by the first or second bolus injection ( P > 0.05) or in the right or left eye ( P > 0.05). Pooled data from all eyes were analyzed. Peak intensity of ROI 2 was significantly higher compared to all other ROIs ( P < 0.001). Area under the curve at ROI 2 was significantly higher compared to all other ROIs ( P < 0.05), and AUC at ROI 1 was significantly higher than at ROI 4 ( P < 0.05). No significant differences in TTP were observed between different ROIs ( P > 0.05). Ratios relative to different ROI sizes showed fastest enhancement in the retrobulbar cone and most intense perfusion in the anterior uveal regions. The first minute after contrast injection provided the highest diagnostic value.

          Conclusion

          Quantitative perfusion in nondiseased canine eyes revealed consistent parameters. Application of standardized CEUS protocols may be a promising diagnostic tool to differentiate ocular lesions.

          Related collections

          Most cited references 39

          • Record: found
          • Abstract: not found
          • Article: not found

          The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Development and validation of a body condition score system for dogs

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Contrast-enhanced ultrasound is helpful in the differentiation of malignant and benign breast lesions.

              To evaluate the significance of contrast-enhanced ultrasound (CEUS) examination in differential diagnosis of malignant and benign breast lesions. Seventy-one patients with seventy-six breast tumors are selected randomly. CEUS examinations were performed before and after bolus injection of the contrast agent SonoVue (Bracco, Milan, Italy). Specific sonographic quantification software, Qontrast, was adopted to determine the morphology of vessels. Wash-in and wash-out parameters of each lesion were assessed for both procedures. The final histopathological findings distinguished 45 malignant and 31 benign from all of the lesions. Following SonoVue administration different perfusion phases could be identified: early (0-1min), mid (1-4min) and late (4-6min) phases. In the early phase, CEUS identified 91.1% of malignant tumors characterized by a claw-shaped enhancement, while 83.9% of benign tumors had a homogeneous enhancement, with a statistically significant difference between the two enhancement patterns (chi(2)=43.16, P<0.01). Moreover, contrast medium persistence in the late phase was helpful in the identification of benign and malignant tumors (chi(2)=46.88, P<0.01): contrast medium was present in 88.9% of malignant tumors, while in only 9.7% of the benign tumors. The study showed that various parametric imaging color maps for peak intensity and time to peak were mostly suggestive of malignancy, while quite uniform peak intensity and time to peak of color maps were the characteristic of benign tumors. The study also found that malignant lesions presented with a higher maximum intensity signal than benign ones (P<0.05) on the time-intensity curves. CEUS cooperating with conventional US shows improved accuracy in differentiating between malignant and benign breast tumors. It could be a reliable diagnostic method of breast lesions. Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.
                Bookmark

                Author and article information

                Contributors
                klaas-ole.blohm@vetmeduni.ac.at
                Journal
                Vet Ophthalmol
                Vet Ophthalmol
                10.1111/(ISSN)1463-5224
                VOP
                Veterinary Ophthalmology
                John Wiley and Sons Inc. (Hoboken )
                1463-5216
                1463-5224
                17 February 2019
                November 2019
                : 22
                : 6 ( doiID: 10.1111/vop.v22.6 )
                : 767-777
                Affiliations
                [ 1 ] Department for Companion Animals and Horses, Ophthalmology Service University of Veterinary Medicine Vienna Austria
                [ 2 ] Department for Companion Animals and Horses, Diagnostic Imaging University of Veterinary Medicine Vienna Austria
                [ 3 ] Department of Biomedical Sciences University of Veterinary Medicine Vienna Austria
                Author notes
                [* ] Correspondence

                Klaas‐Ole Blohm, Department for Companion Animals and Horses, Ophthalmology Service, University of Veterinary Medicine, Vienna, Austria.

                Email: klaas-ole.blohm@ 123456vetmeduni.ac.at

                Article
                VOP12648
                10.1111/vop.12648
                6899557
                30773789
                © 2019 University of Veterinary Medicine Vienna. Veterinary Ophthalmology published by Wiley Periodicals Inc. on behalf of American College of Veterinary Ophthalmologists

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                Page count
                Figures: 5, Tables: 3, Pages: 11, Words: 6452
                Product
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                November 2019
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.2 mode:remove_FC converted:05.12.2019

                Comments

                Comment on this article