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      Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64

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          Abstract

          <p class="first" id="d14038782e234"> <div class="figure-container so-text-align-c"> <img alt="" class="figure" src="/document_file/9a2d880e-1c5c-4c62-b3ca-8e8686ca22dc/PubMedCentral/image/ml-2015-00362n_0009"/> </div> </p><p id="d14038782e238">A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, <sup>64</sup>Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A). </p>

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          Author and article information

          Journal
          Title: ACS Medicinal Chemistry Letters
          Abbreviated Title: ACS Med. Chem. Lett.
          Publisher: American Chemical Society (ACS)
          ISSN (Print): 1948-5875
          ISSN (Electronic): 1948-5875
          Publication date Created: October 06 2015
          Publication date Created: November 12 2015
          Publication date (Electronic): October 20 2015
          Publication date (Print): November 12 2015
          Volume: 6
          Issue: 11
          Pages: 1162-1166
          Affiliations
          [1 ]Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu 700-422, South Korea
          [2 ]Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, South Korea
          [3 ]Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science &amp; Technology, Daegu 711-873, South Korea
          [4 ]Western Seoul Center, Korea Basic Science Institute, Seoul 120-140, Korea
          Article
          DOI: 10.1021/acsmedchemlett.5b00362
          PMC ID: 4645244
          PubMed ID: 26617972
          SO-VID: d8f6ab78-a70a-40b4-b3f0-15e840b298df
          Copyright © © 2015
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