Impact of Pill Sharing on Drug Resistance Due to a Wide-Scale Oral Prep Intervention in Generalized Epidemics.

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Abstract

The first antiretroviral drug (Truvada) to be used as a pre-exposure prophylaxis (PrEP) in preventing HIV transmission is about to be approved. Behavioral studies suggest that a portion of users may share anti-retroviral drugs with sex partners, family, or friends. Pill sharing will decrease PrEP efficacy and adherence level, and potentially create an environment favorable for the development of drug resistance. We aim to evaluate the potential impact of pill sharing on the PrEP effectiveness and on the rates of drug-resistance development in heterosexual populations.

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Author and article information

Journal

Journal ID (iso-abbrev): J AIDS Clin Res

Title: Journal of AIDS & clinical research

Publication date (Electronic): Jul 8 2012

Volume: Suppl 5

Issue: 4

Affiliations

[1 ] Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, USA.

[2 ] Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK.

[3 ] CHU Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada.

Article

Mid ID: NIHMS479010

PMC ID: 3870903

PubMed ID: 24371543

SO-VID: d90ab464-3b09-42ad-9ca8-a9b2383fc088

History

Keywords: HIV,Pill sharing,Pre-exposure prophylaxis

Data availability:

Keywords: HIV, Pill sharing, Pre-exposure prophylaxis

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