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      Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells.

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          Abstract

          Cancer cells require massive amounts of amino acids for survival. LAT1 (L-type amino acid transporter 1) transports essential amino acids, including leucine, which trigger the downstream mTOR (mammalian target of rapamycin) pathway. We examined the association between androgen receptor and LAT1, and the association between LAT1 expression and the acquisition of castration resistance.

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          Author and article information

          Journal
          J. Urol.
          The Journal of urology
          Elsevier BV
          1527-3792
          0022-5347
          May 2016
          : 195
          : 5
          Affiliations
          [1 ] Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.
          [2 ] Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan. Electronic address: rbatbat1@yahoo.co.jp.
          [3 ] Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba, Japan.
          [4 ] Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan.
          [5 ] Prostate Center and Division of Urology, Chiba Cancer Center, Chiba, Japan.
          [6 ] Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
          [7 ] Division of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan.
          Article
          S0022-5347(15)05395-1
          10.1016/j.juro.2015.11.071
          26682754
          d9537e79-7d28-4ebf-9e61-8767136d423d
          History

          androgen antagonists,castration,large neutral amino acid-transporter 1,prostatic neoplasms,treatment failure

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