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Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function.
Alain C Mita
1 ,
Christopher J Sweeney ,
Sharyn D Baker ,
Andrew Goetz ,
Lisa A Hammond ,
Amita Patnaik ,
Anthony W Tolcher ,
Miguel Villalona-Calero ,
Alan Sandler ,
Tuhin Chaudhuri ,
Kathleen Molpus ,
Jane E Latz ,
Lorinda Simms ,
Ajai K Chaudhary ,
Robert D Johnson ,
Eric K Rowinsky ,
Chris H Takimoto
Feb 01 2006
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Abstract
This phase I study was conducted to determine the toxicities, pharmacokinetics, and recommended doses of pemetrexed in cancer patients with normal and impaired renal function.