26
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Autovaloración de calidad de vida y envejecimiento en adultos con riesgo de Alzheimer Translated title: Self-assessment of quality of life and aging of Alzheimer development risk adults

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Objetivo: describir la autovaloración de calidad de vida y del envejecimiento de tres grupos: adultos portadores y no portadores de la mutación E280A en el gen de la Presenilina 1 para Enfermedad de Alzheimer Familiar Precoz, y adultos mayores, en Antioquia-Colombia, estudio realizado entre enero de 2005 y junio de 2007. Metodología: estudio descriptivo transversal donde participaron 162 personas asintomáticas en riesgo de desarrollar Enfermedad de Alzheimer como consecuencia genética o del proceso de envejecimiento, quienes se subdividieron en tres grupos: 27 portadores, 39 no portadores y 96 adultos mayores. Investigación realizada en el Grupo de Neurociencias de la Universidad de Antioquia (Medellín) y en el Centro Gerontológico Atardecer (Envigado). Se analizaron las características sociodemográficas, y se aplicaron pruebas para la autovaloración de la calidad de vida global del envejecimiento: World Health Organization Quality of Life y la Nürnberg -Self-Evaluation-List respectivamente. Análisis estadístico: Se describieron los grupos y se compararon frente a las variables de estudio utilizando el análisis de varianza no paramétrico de Kruskall Wallis y la prueba U de Mann-Whitney. Resultados: las calificaciones medias de los instrumentos para la autovaloración de calidad de vida y global del envejecimiento en los tres grupos de participantes, fueron superiores a 50 puntos e inferiores a 55 puntos respectivamente. Conclusiones: los adultos mayores se autovaloran con menor calidad de vida que los portadores y los no portadores, especialmente en el área de salud física, al igual que en la percepción del envejecimiento, a pesar de las condiciones de los portadores, aunque, en general, todos los grupos las puntuaron bien.

          Translated abstract

          Objective: describe the self assessment of the quality of life and the aging of a group of middle-age adult carriers and non-carriers of mutation E280A in gene Presenilin 1 for Early Onset Familial Alzheimer’s Disease and of elderly adults in Antioquia- Colombia. Study conducted from January 2005 to June 2007. Methodology: descriptive transversal study in which 162 asymptomatic people at risk of developing Alzheimer’s disease as a genetic consequence or as a consequence of the process of aging. They were subdivided into three groups: 27 carriers of the mutation, 39 non-carriers and 96 elderly adults. The study was conducted at the Neuroscience Group in Medellín (Antioquia) and at a gerontology center in Envigado (Antioquia) named Atardecer. Social-demographic characteristics were analyzed and quality of life and overall aging selfassessment tests were applied, which included the World Health Organization Quality of Life, and the Nürnberg -Self-Evaluation-List respectively. Statistic Analysis: The groups were described and they were compared to the variables of the study using Kruskall Wallis non-parametric anova and Mann-Whitney’s U-test. Results: the mean scores of the instruments to assess quality of life and overall aging of three groups of participants were above 50 points and below 55 points respectively. Conclusions: elderly adults assessed themselves as having a lower quality of life than carriers and non-carriers, especially in the physical health area, and in their perception of aging, in spite of carriers’ conditions, although in general the scores were good in all the groups.

          Related collections

          Most cited references54

          • Record: found
          • Abstract: not found
          • Article: not found

          Mini-mental state: A practical method for grading the cognitive state of patients for the clinician

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Calidad de vida relacionada con la salud: aspectos conceptuales

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.

              To characterize clinical features of a very large pedigree with early-onset Alzheimer disease (AD) in which all affected individuals carry the identical glutamic acid-to-alanine mutation at codon 280 in the presenilin-1 gene. Clinical histories were obtained by patient and family interviews and through medical or civil records. Using standard diagnostic criteria, a case series of 128 individuals was identified, of which 6 have definitive (autopsy-proven) early-onset AD, 93 have probable early-onset AD, and 29 have possible early-onset AD. Community based in Antioquia, Colombia. A population-based sample in which all members of 5 extended families (nearly 3000 individuals) were surveyed. Criteria for inclusion required obtaining sufficient information to categorize the individual as affected. Age at onset, neuropsychological profile, neurologic history, and examination. The patients had a mean age at onset of 46.8 years (range, 34-62 years). The average interval until death was 8 years. Headache was noted in affected individuals significantly more frequently than in those not affected. The most frequent presentation was memory loss followed by behavior and personality changes and progressive loss of language ability. In the final stages, gait disturbances, seizures, and myoclonus were frequent. Other than the early onset, this clinical phenotype is indistinguishable from sporadic AD except that affected individuals frequently complained of headache preceding and during the disease. Despite the uniform genetic basis for the disease, there was significant variability in the age at onset, suggesting an important role for environmental factors or genetic modifiers in determining the age at onset.
                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: COORD
                Role: ND
                Role: ND
                Role: ND
                Journal
                iee
                Investigación y Educación en Enfermería
                Invest. educ. enferm
                Imprenta Universidad de Antioquia (Medellín )
                0120-5307
                March 2008
                : 26
                : 1
                : 24-35
                Affiliations
                [1 ] Universidad de Antioquia Colombia
                [2 ] Grupo de Neurociencias de Antioquia Colombia
                [3 ] Grupo de Neurociencias de Antioquia Colombia
                [4 ] Universidad de Antioquia Colombia
                [5 ] Grupo de Neurociencias de Antioquia Colombia
                [6 ] Grupo de Neurociencias de Antioquia Colombia
                [7 ] Universidad Erlangen-Nürnberg Germany
                [8 ] Universidad Erlangen-Nürnberg Germany
                Article
                S0120-53072008000100002
                d95e74ce-866b-4b81-9113-ac92898dbb12

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Colombia

                Self URI (journal page): http://www.scielo.org.co/scielo.php?script=sci_serial&pid=0120-5307&lng=en
                Categories
                NURSING

                Nursing
                self-assessment,quality of life,aging,Alzheimer’s disease,autovaloración,calidad de vida,envejecimiento,enfermedad de Alzheimer

                Comments

                Comment on this article