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      Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.

      1 ,
      Cell stem cell
      Elsevier BV

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          Abstract

          Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify chromatin and participate in the establishment and maintenance of cell fates. These proteins play important roles in both stem cell self-renewal and in cancer development. Our understanding of their mechanism of action has greatly advanced over the past 10 years, but many unanswered questions remain. In this review, we present the currently available experimental data that connect PcG protein function with some of the key processes which govern somatic stem cell activity. We also highlight recent studies suggesting that a delicate balance in PcG gene dosage is crucial for proper stem cell homeostasis and prevention of cancer stem cell development.

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          Author and article information

          Journal
          Cell Stem Cell
          Cell stem cell
          Elsevier BV
          1875-9777
          1875-9777
          Sep 03 2010
          : 7
          : 3
          Affiliations
          [1 ] Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer, University of Montreal, Montreal, QC H3C 3J7, Canada. guy.sauvageau@umontreal.ca
          Article
          S1934-5909(10)00394-2 CAMS4436
          10.1016/j.stem.2010.08.002
          4959883
          20804967
          d98992c5-0ee5-483b-9a47-cb1827854e1c
          Copyright 2010 Elsevier Inc. All rights reserved.
          History

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