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Exercise moderates age-related atrophy of the medial temporal lobe
Author(s):
Julie M. Bugg
,
Denise Head
Publication date
Created:
March 2011
Publication date
(Print):
March 2011
Journal:
Neurobiology of Aging
Publisher:
Elsevier BV
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Abstract
Regional deterioration of brain structure is a typical feature of aging, but emerging evidence suggests that exercise may mitigate the decline. The purpose of the present investigation was to examine the moderating influence of exercise engagement on cross-sectional estimates of age-related brain atrophy at both global and regional levels. Estimates of exercise engagement over the past 10 years and MRI-based measures of global (gray and white) and regional volumes were obtained in a sample of 52 healthy older adults aged 55-79. Volume estimates were obtained in prefrontal, parietal, temporal, occipital, neostriatal, and medial temporal regions. Higher levels of exercise engagement were related to larger superior frontal volumes. Most critically, exercise engagement selectively moderated age-related medial temporal lobe atrophy. Specifically, significant age-related atrophy was observed for older adults who engaged in low levels of exercise, but not for those who engaged in high levels of exercise. This novel finding extends support for the efficacy of exercise to the potential maintenance of medial temporal lobe integrity in older adults. Copyright © 2009 Elsevier Inc. All rights reserved.
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Author and article information
Journal
Title:
Neurobiology of Aging
Abbreviated Title:
Neurobiology of Aging
Publisher:
Elsevier BV
ISSN (Print):
01974580
Publication date Created:
March 2011
Publication date (Print):
March 2011
Volume
: 32
Issue
: 3
Pages
: 506-514
Article
DOI:
10.1016/j.neurobiolaging.2009.03.008
PMC ID:
2891908
PubMed ID:
19386382
SO-VID:
d99c2d38-4fa2-4a23-8f4f-83e0f5e52e9d
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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