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Vascular Smooth Muscle Activity of 7-Oxa-13-Prostynoic Acid
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Abstract
The effects of 7-oxa-13-prostynoic acid (7-OPA), alone and as an antagonist of PGE<sub>2 </sub>and PGF<sub>2α</sub>, were investigated in isolated rabbit aortic and canine renal arterial (diameter ∼0.5 mm) strips. 7-OPA caused contractions in both preparations; threshold concentrations were 3-to 10-fold higher than the PGs and maximum contraction was 50-60%. In concentrations of 10<sup>–5</sup> M, 7-OPA inhibited contractions by PGF<sub>2α</sub> and PGE<sub>2</sub>. The same concentration of 7-OPA did not inhibit norepinephrine-induced contractions. These data indicate that 7-OPA is a partial agonist of PG receptors and produces its antagonism of PGE<sub>2</sub> and PGF<sub>2α</sub> by that mechanism.
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158190 Blood Vessels 1979;16:52–57Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.