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      Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients.

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          Abstract

          We hypothesized that the activity of the hypothalamus-pituitary-adrenal system in depressed patients is related to oral glucose tolerance. In 70 moderately depressed inpatients, we measured morning saliva cortisol for 6 days and assessed oral glucose tolerance. We found glucose concentrations to be positively associated with mean morning cortisol concentrations (F3,236 = 2.86, p < 0.05). Also, the ISI, a measure of insulin receptor sensitivity, was negatively associated with mean morning cortisol concentrations (r = -0.25, p < 0.04). These findings support the hypothesis that hypercortisolemia may lead to disturbed glucose utilization in depressed patients.

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          Author and article information

          Journal
          Neuroendocrinology
          Neuroendocrinology
          0028-3835
          0028-3835
          2005
          : 81
          : 3
          Affiliations
          [1 ] Central Institute of Mental Health, Mannheim, Campus Benjamin Franklin, Department of Psychiatry, Berlin, Germany.
          87003
          10.1159/000087003
          16020929
          (c) 2005 S. Karger AG, Basel

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