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      Efectos antipsoriásico, antiinflamatorio y analgésico del propoleo rojo colectado en Cuba

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          Abstract

          Se evaluaron los efectos antipsoriásico, antiinflamatorio y analgésico de un extracto de propóleo rojo. Este extracto induce la formación de la capa granular en la prueba de la cola de ratón usada como modelo de psoriasis. El propóleo a la dosis de 50 mg/kg (vía oral) mostró actividad antiinflamatoria en el modelo de granuloma por algodón en ratas, así como en la prueba de permeabilidad capilar en el peritoneo de ratas en la dosis de 10 mg/kg. El extracto de propóleo (25 mg/kg, vía oral) presentó propiedades analgésicas en el modelo de estiramiento por ácido acético, mientras que la dosis de 40 mg/kg fue efectiva en la prueba del plato caliente en ratones. Estos resultados demuestran evidencias acerca de la utilidad potencial del propóleo rojo en trastornos inflamatorios y particularmente en el tratamiento de la psoriasis.

          Translated abstract

          The antipsoriatic, antiinflammatory, and analgesic effects of a red propolis extract, were assessed. This extract induces the formation of a granular layer in the mouse tail test, used as a model for psoriasis. Propolis at a 50 mg/kg dose (oral) showed antiinflammatory activity in the cotton granuloma model in rats, as well as in the capillary permeability test in rats peritoneum at a 10 mg/kg dose. Propolis extract (25 mg/kg, oral) presented analgesic properties in the acetic acid stretching model, while the 40 mg/kg dose was effective in the hot plate test in mice. These results demonstrate evidence about the potential usefulness of red propolis in inflammatory disorders, and particularly, in the management of psoriasis.

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          Most cited references13

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          Flavonoids, a class of natural products of high pharmacological potency.

          B Havsteen (1983)
          A review has been presented of the biochemistry and pharmacology of a class of natural products, the flavonoids. These substances which are widely distributed in the plant kingdom and present in considerable quantities in common food products, spices and beverages have in a concentrated form (Propolis) been used since ancient times by physicians and laymen to treat a great variety of human diseases but they have yet to pass the tests of modern, controlled, clinical experimentation. An attempt has been made to present the fundamental evidence from the basic biological sciences which is required to stimulate the interest of the clinicians in this new field. The few existing reports on the careful pharmacodynamic, pharmacokinetic and clinical studies which have been made have been summarized to provide a basis for a full-scale investigation of the therapeutic potential of flavonoids.
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            Phytochemical evidence for the botanical origin of tropical propolis from Venezuela

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              Identification by Gas Chromatography-Mass Spectrometry of 150 Compounds in Propolis

              Propolis was analyzed by gas chromatography-mass spectrometry for both its headspace volatiles and for the less volatile components of its alcoholic extract (propolis balsam). 181 peaks were located of which 171 representing 150 compounds were identified, including 28 identified in propolis for the first time. The majority of compounds were typical of poplar bud exudate.
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                Author and article information

                Journal
                far
                Revista Cubana de Farmacia
                Rev Cubana Farm
                Editorial Ciencias Médicas (Ciudad de la Habana, , Cuba )
                0034-7515
                1561-2988
                April 1996
                : 30
                : 1
                Affiliations
                [01] Ciudad de La Habana orgnameCentro Nacional de Investigaciones Científicas Cuba
                Article
                S0034-75151996000100008 S0034-7515(96)03000108
                da05a419-ba1c-4b96-a498-16c24bd0c771

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 20 December 1995
                : 22 January 1996
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 12, Pages: 0
                Product

                SciELO Cuba

                Categories
                ARTICULOS ORIGINALES

                CLINICAL TRIALS,RATS,INBRED STRAINS,MICE,CUBA,PROPOLIS,AGENTES ANTIINFLAMATORIOS,ANALGESICOS,ANTIPSORICOS,ENSAYOS CLINICOS,RATAS DE CEPAS CONSANGUINEAS,RATONES,ANTIINFLAMMATORY AGENTS,ANALGESICS,ANTIPSORICS

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