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Type I IFN family members: Similarity, differences and interaction
research-article
31 October 2014
ADAR1, adenosine deaminase acting on RNA 1,
AP-1, activator protein 1,
APCs, antigen presenting cells,
ATF6, activating transcription factor 6,
BCG, bacille Calmette–Guérin,
cGAS, cyclic GMP-AMP synthase,
CHIKV, Chickungunya virus,
CRF2, class II cytokine receptor family,
ds, double strand,
EAE, experimental allergic encephalomyelitis,
EM, environmental mycobacteria,
EMCV, encephalomyocarditis virus,
GAS, gamma interferon activation site,
hCMV, human Cytomegalovirus,
HCV, hepatitis C virus,
HSE, herpes simplex encephalitis,
HSV-1, herpes simplex virus-1,
IFI16, gamma-interferon-inducible protein 16,
IFN, interferon,
IFNAR, interferon alpha receptor,
IFNGR, interferon gamma receptor,
IL, interleukin,
IPS-1, interferon promoter-stimulating factor 1,
IRAK-4, interleukin-1 receptor-associated kinase 4,
IRF, interferon regulatory factor,
ISGF3, interferon-stimulated gene factor 3,
ISRE, interferon stimulated response element,
JAK, Janus kinase,
LASV, Lassa virus,
MAPK, mitogen-activated protein kinases,
MDA5, melanoma differentiation-associated protein 5,
MHC, major histocompatibility complex,
MS, multiple sclerosis,
MSMD, Mendelian susceptibility to mycobacterial disease,
MxA, Myxovirus Resistance Gene A,
NEMO, nuclear factor (NF)-kB essential modulator,
NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells,
NK, natural killer cells,
OAS, 2′,5′-oligo adenylate synthetase A,
p300/CBP, chromatin remodeling associated p300/CREB-binding protein,
PD-L1, programmed death ligand 1,
PKR, dsRNA-dependent protein kinase,
PRRs, pattern-recognition receptors,
RIG-1, retinoic-acid-inducible gene 1,
SAMHD1, SAM domain and HD domain-containing protein 1,
SARS, severe acute respiratory syndrome,
SARS-CoV, severe acute respiratory syndrome-associated coronavirus,
SNPs, single nucleotide polymorphisms,
SOCS, suppressor of cytokine signaling,
ss, single strand,
STAT, Signal Transducer and Activator of Transcription,
Th, lymphocytes T helper,
TLR, Toll-like receptor,
TREX1, three prime repair exonuclease 1,
TYK2, tyrosine kinase 2,
VSV, vesicular stomatitis virus,
VZV, Varicella-Zoster virus,
WNV, West Nile virus,
Interferon types I–III,
Interferon genes and receptors,
Interferon–interferon interactions,
Anti-interferon strategies
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Abstract
Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I–III) based on structural features, receptor usage, cellular source and biological activities. The action of IFNs is mediated by a complex, partially overlapping, transcriptional program initiated by the interaction with specific receptors. Genetic diversity, with polymorphisms and mutations, can modulate the extent of IFN responses and the susceptibility to infections. Almost all viruses developed mechanisms to subvert the IFN response, involving both IFN induction and effector mechanisms. Interactions between IFN types may occur, for both antiviral and cell-modulatory effects, in a complex interplay, involving both synergistic and antagonistic effects. Interferon-associated diseases, not related to virus infections may occur, some of them frequently observed in IFN-treated patients. On the whole, IFNs are pleiotropic biologic response modifiers, that, upon activation of thousands genes, induce a broad spectrum of activities, regulating cell cycle, differentiation, plasma membrane molecules, release of mediators, etc., that can be relevant for cell proliferation, innate and adaptive immunity, hematopoiesis, angiogenesis and other body functions.
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Most cited references89
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- Abstract: found
- Article: not found
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
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IL-28, IL-29 and their class II cytokine receptor IL-28R.
Paul Sheppard, Wayne Kindsvogel, Wenfeng Xu … (2003)
Author and article information
adar1, adenosine deaminase acting on rna 1,ap-1, activator protein 1,apcs, antigen presenting cells,atf6, activating transcription factor 6,bcg, bacille calmette–guérin,cgas, cyclic gmp-amp synthase,chikv, chickungunya virus,crf2, class ii cytokine receptor family,ds, double strand,eae, experimental allergic encephalomyelitis,em, environmental mycobacteria,emcv, encephalomyocarditis virus,gas, gamma interferon activation site,hcmv, human cytomegalovirus,hcv, hepatitis c virus,hse, herpes simplex encephalitis,hsv-1, herpes simplex virus-1,ifi16, gamma-interferon-inducible protein 16,ifn, interferon,ifnar, interferon alpha receptor,ifngr, interferon gamma receptor,il, interleukin,ips-1, interferon promoter-stimulating factor 1,irak-4, interleukin-1 receptor-associated kinase 4,irf, interferon regulatory factor,isgf3, interferon-stimulated gene factor 3,isre, interferon stimulated response element,jak, janus kinase,lasv, lassa virus,mapk, mitogen-activated protein kinases,mda5, melanoma differentiation-associated protein 5,mhc, major histocompatibility complex,ms, multiple sclerosis,msmd, mendelian susceptibility to mycobacterial disease,mxa, myxovirus resistance gene a,nemo, nuclear factor (nf)-kb essential modulator,nf-κb, nuclear factor kappa-light-chain-enhancer of activated b cells,nk, natural killer cells,oas, 2′,5′-oligo adenylate synthetase a,p300/cbp, chromatin remodeling associated p300/creb-binding protein,pd-l1, programmed death ligand 1,pkr, dsrna-dependent protein kinase,prrs, pattern-recognition receptors,rig-1, retinoic-acid-inducible gene 1,samhd1, sam domain and hd domain-containing protein 1,sars, severe acute respiratory syndrome,sars-cov, severe acute respiratory syndrome-associated coronavirus,snps, single nucleotide polymorphisms,socs, suppressor of cytokine signaling,ss, single strand,stat, signal transducer and activator of transcription,th, lymphocytes t helper,tlr, toll-like receptor,trex1, three prime repair exonuclease 1,tyk2, tyrosine kinase 2,vsv, vesicular stomatitis virus,vzv, varicella-zoster virus,wnv, west nile virus,interferon types i–iii,interferon genes and receptors,interferon–interferon interactions,anti-interferon strategies
adar1, adenosine deaminase acting on rna 1, ap-1, activator protein 1, apcs, antigen presenting cells, atf6, activating transcription factor 6, bcg, bacille calmette–guérin, cgas, cyclic gmp-amp synthase, chikv, chickungunya virus, crf2, class ii cytokine receptor family, ds, double strand, eae, experimental allergic encephalomyelitis, em, environmental mycobacteria, emcv, encephalomyocarditis virus, gas, gamma interferon activation site, hcmv, human cytomegalovirus, hcv, hepatitis c virus, hse, herpes simplex encephalitis, hsv-1, herpes simplex virus-1, ifi16, gamma-interferon-inducible protein 16, ifn, interferon, ifnar, interferon alpha receptor, ifngr, interferon gamma receptor, il, interleukin, ips-1, interferon promoter-stimulating factor 1, irak-4, interleukin-1 receptor-associated kinase 4, irf, interferon regulatory factor, isgf3, interferon-stimulated gene factor 3, isre, interferon stimulated response element, jak, janus kinase, lasv, lassa virus, mapk, mitogen-activated protein kinases, mda5, melanoma differentiation-associated protein 5, mhc, major histocompatibility complex, ms, multiple sclerosis, msmd, mendelian susceptibility to mycobacterial disease, mxa, myxovirus resistance gene a, nemo, nuclear factor (nf)-kb essential modulator, nf-κb, nuclear factor kappa-light-chain-enhancer of activated b cells, nk, natural killer cells, oas, 2′,5′-oligo adenylate synthetase a, p300/cbp, chromatin remodeling associated p300/creb-binding protein, pd-l1, programmed death ligand 1, pkr, dsrna-dependent protein kinase, prrs, pattern-recognition receptors, rig-1, retinoic-acid-inducible gene 1, samhd1, sam domain and hd domain-containing protein 1, sars, severe acute respiratory syndrome, sars-cov, severe acute respiratory syndrome-associated coronavirus, snps, single nucleotide polymorphisms, socs, suppressor of cytokine signaling, ss, single strand, stat, signal transducer and activator of transcription, th, lymphocytes t helper, tlr, toll-like receptor, trex1, three prime repair exonuclease 1, tyk2, tyrosine kinase 2, vsv, vesicular stomatitis virus, vzv, varicella-zoster virus, wnv, west nile virus, interferon types i–iii, interferon genes and receptors, interferon–interferon interactions, anti-interferon strategies