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      Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity : Symptomatic Knee OA in the US

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          Abstract

          The prevalence of symptomatic knee osteoarthritis (OA) has been increasing over the past several decades in the US, concurrent with an aging population and the growing obesity epidemic. We quantify the impact of these factors on the number of persons with symptomatic knee OA in the early decades of the 21st century.

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          Most cited references 29

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          The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review.

          To understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints. A systematic review was carried out in PUBMED and SCOPUS databases comprising the date of publication period from January 1995 to February 2011. We attempted to summarise data on the incidence and prevalence of OA according to different methods of assessment: self-reported, radiographic and symptomatic OA (clinical plus radiographic). Prevalence estimates were combined through meta-analysis and between-study heterogeneity was quantified. Seventy-two papers were reviewed (nine on incidence and 63 on prevalence). Higher OA prevalences are seen when radiographic OA definition was used for all age groups. Prevalence meta-analysis showed high heterogeneity between studies even in each specific joint and using the same OA definition. Although the knee is the most studied joint, the highest OA prevalence estimates were found in hand joints. OA of the knee tends to be more prevalent in women than in men independently of the OA definition used, but no gender differences were found in hip and hand OA. Insufficient data for incidence studies didn't allow us to make any comparison according to joint site or OA definition. Radiographic case definition of OA presented the highest prevalences. Within each joint site, self-reported and symptomatic OA definitions appear to present similar estimates. The high heterogeneity found in the studies limited further conclusions. Copyright © 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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            Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study.

            To investigate the relationship between body mass index (BMI) and the incidence and progression of radiological knee as well as of radiological hip osteoarthritis. Cohort study. Population based. 3585 people aged > or =55 years were selected from the Rotterdam Study, on the basis of the availability of radiographs of baseline and follow-up. Incidence of knee or hip osteoarthritis was defined as minimally grade 2 at follow-up and grade 0 or 1 at baseline. The progression of osteoarthritis was defined as a decrease in joint space width. x Rays of the knee and hip at baseline and follow-up (mean follow-up of 6.6 years) were evaluated. BMI was measured at baseline. A high BMI (>27 kg/m(2)) at baseline was associated with incident knee osteoarthritis (odds ratio (OR) 3.3), but not with incident hip osteoarthritis. A high BMI was also associated with progression of knee osteoarthritis (OR 3.2). For the hip, a significant association between progression of osteoarthritis and BMI was not found. On the basis of these results, we conclude that BMI is associated with the incidence and progression of knee osteoarthritis. Furthermore, it seems that BMI is not associated with the incidence and progression of hip osteoarthritis.
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              Estimating the burden of total knee replacement in the United States.

              In the last decade, the number of total knee replacements performed annually in the United States has doubled, with disproportionate increases among younger adults. While total knee replacement is a highly effective treatment for end-stage knee osteoarthritis, total knee replacement recipients can experience persistent pain and severe complications. We are aware of no current estimates of the prevalence of total knee replacement among adults in the U.S.
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                Author and article information

                Journal
                Arthritis Care & Research
                Arthritis Care & Research
                Wiley
                2151464X
                December 2016
                December 2016
                November 03 2016
                : 68
                : 12
                : 1743-1750
                Affiliations
                [1 ]Brigham and Women's Hospital; Boston Massachusetts
                [2 ]Brigham and Women's Hospital, Harvard Medical School, and Harvard T. H. Chan School of Public Health; Boston Massachusetts
                [3 ]Brigham and Women's Hospital and Harvard Medical School; Boston Massachusetts
                [4 ]Philip R. Lee Institute for Health Policy Studies and Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California; San Francisco
                [5 ]Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia, and Royal North Shore Hospital; St. Leonards New South Wales Australia
                [6 ]Wake Forest School of Medicine, Wake Forest University; Winston-Salem North Carolina
                [7 ]Yale School of Medicine and Yale-New Haven Hospital, New Haven, Connecticut, and Veterans Affairs Connecticut Healthcare System; West Haven Connecticut
                [8 ]Brigham and Women's Hospital, Harvard Medical School, and Boston University School of Public Health; Boston Massachusetts
                Article
                10.1002/acr.22897
                5319385
                27014966
                © 2016

                http://doi.wiley.com/10.1002/tdm_license_1.1

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