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      Trends in primary multidrug-resistant tuberculosis in the State of Rio de Janeiro: a retrospective study conducted during 2000-2019

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      Author(s): 1 , 2 , 1
      Publication date (Electronic, pub):
      Publication date (Electronic, collection):
      Journal: Revista da Sociedade Brasileira de Medicina Tropical
      Publisher: Sociedade Brasileira de Medicina Tropical - SBMT
      Keywords: Tuberculosis, Epidemiological monitoring, Drug resistance, Time-series studies

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          Abstract

          INTRODUCTION:

          We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB).

          METHODS:

          We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis.

          RESULTS:

          The percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001).

          CONCLUSIONS:

          The trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.

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          Most cited references15

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          Global Tuberculosis Report 2020

          (2020)
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            Brasil Livre da Tuberculose: evolução dos cenários epidemiológicos e operacionais da doença

            BRASIL, Md Saúde, SdV em (2019)
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              Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000-2016

              Marcela Bhering, Raquel Duarte, Afranio L. Kritski (2019)
              Setting The State of Rio de Janeiro stands out as having the second highest incidence and the highest mortality rate due to TB in Brazil. This study aims at identifying the factors associated with the unfavourable treatment of MDR/XDR-TB patients in that State. Method Data on 2269 MDR-TB cases reported in 2000–2016 in Rio de Janeiro State were collected from the Tuberculosis Surveillance System. Bivariate and multivariate logistic regressions were run to estimate the factors associated with unfavourable outcomes (failure, default, and death) and, specifically, default and death. Results The proportion of unfavourable outcomes was 41.9% among MDR-TB and 81.5% among XDR-TB. Having less than 8 years of schooling, and being an Afro-Brazilian, under 40 years old and drug user were associated with unfavourable outcome and default. Bilateral disease, HIV positive, and comorbidities were associated with death. XDR-TB cases had a 4.7-fold higher odds of an unfavourable outcome, with 29.3% of such cases being not treated for multidrug resistance in the past. Conclusion About 30% of XDR-TB cases may have occurred by primary transmission. The high rates of failure and death in this category reflect the limitation of treatment options. This highlights the urgency to incorporate new drugs in the treatment.
              Article 0 comments Cited 19 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Rev Soc Bras Med Trop
                Journal ID (iso-abbrev): Rev Soc Bras Med Trop
                Journal ID (publisher-id): rsbmt
                Title: Revista da Sociedade Brasileira de Medicina Tropical
                Publisher: Sociedade Brasileira de Medicina Tropical - SBMT
                ISSN (Print): 0037-8682
                ISSN (Electronic): 1678-9849
                Publication date (Electronic, pub): 20 August 2021
                Publication date (Electronic, collection): 2021
                Volume: 54
                Electronic Location Identifier: e0086-2021
                Affiliations
                [1 ] Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa Acadêmico de Tuberculose, Rio de Janeiro, RJ, Brasil.
                [2 ] Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública Sergio Arouca, Rio de Janeiro, RJ, Brasil.
                Author notes
                Corresponding author: Marcela Bhering. e-mail: marbhering@ 123456gmail.com

                Authors' contribution: MB: conception and design of the study, data acquisition, analysis, and interpretation of data, and drafting the article. AK: analysis and interpretation of data, drafting the paper, and final approval of the version to be submitted.

                Conflict of Interest: The authors declare that there is no conflict of interest.

                Author information
                http://orcid.org/0000-0002-1568-026X
                http://orcid.org/0000-0002-5900-6007
                Article
                Other ID: 00651
                DOI: 10.1590/0037-8682-0086-2021
                PMC ID: 8405210
                PubMed ID: 34431941
                SO-VID: da24a9e0-2460-42cf-a967-f3d96806fcba
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License

                History
                Date received : 12 February 2021
                Date accepted : 08 July 2021
                Page count
                Figures: 1, Tables: 1, Equations: 0, References: 14
                Categories
                Subject: Short Communication

                Keywords: tuberculosis,epidemiological monitoring,drug resistance,time-series studies
                Data availability:
                Keywords: tuberculosis, epidemiological monitoring, drug resistance, time-series studies

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