A Monoclonal Antibody which Identifies an Antigen in Endothelial Cell and Epithelial Basement Membrane

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Abstract

We isolated a monoclonal antibody which decorates the endothelial cells of normal and lymphatic vessels in formalin-fixed, paraffin-embedded tissue. In addition, the antibody recognizes a previously undescribed substance found in the basement membrane zone and subbasement membrane zone of a variety of epithelia. By ELISA assay, the antigen recognized by this monoclonal antibody is not laminin, type IV collagen or fibronectin. This antibody may be used as a diagnostic tool because it identifies an epitope in neoplasms differentiating towards endothelial cell such as angiosarcoma and Kaposi’s sarcoma.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1990

Publication date (Print): 1990

Publication date (Electronic): 23 September 2008

Volume: 27

Issue: 1

Pages: 14-23

Affiliations

^aDepartment of Dermatology, Asahikawa Medical College, Hokkaido, Japan; ^bDepartment of Dermatology, University of Miami School of Medicine, Miami, Fla.; Departments of ^cDermatology, ^dMedicine, and ^c,dLM-EM-Histochemistry Unit, Institute of Dental Research, University of Alabama School of Medicine, Birmingham, Ala.; ^cDermatology Service, Birmingham Veterans Administration Medical Center, Birmingham, Ala.; ^eDepartment of Pathology, University of Miami School of Medicine, Miami, Fla., USA

Article

Publisher ID: 158792 Other ID: Blood Vessels 1990;27:14–23

DOI: 10.1159/000158792

SO-VID: da3c954d-e65f-4105-868a-3b9bda51447b

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 21 September 1988

Date accepted : 16 November 1989

Page count

Pages: 10

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