Research update on the effect of irisin/FNDC5 on metabolism of children and adolescents

Abstract

The metabolic level of children and adolescents is of great significance in the healthy growth and development of children and adolescents. Irisin, as a myokine, was first discovered and named in 2012. Early studies showed that irisin can participate in body metabolism and inhibit the occurrence of obesity. Later studies found that irisin can improve the symptoms of type 2 diabetes mellitus, metabolic syndrome, osteoporosis and other diseases. At the same time, irisin can promote glucose, lipid metabolism and bone metabolism in children and adolescents, and its mechanism is still controversial. In this review, research update regarding the effect of irisin/FNDC5 on metabolism (lipid metabolism, glucose metabolism, bone metabolism) in children and adolescents were summarized in order to provide theoretical reference for researchers in the field of the metabolism of children and adolescents.

Abstract

【摘要】 儿童青少年身体代谢水平在儿童青少年的健康成长发育方面具有重要意义。鸾尾素 (Irisin) 作为一种肌肉因子, 于 2012 年被首次发现并命名, 早期研究结果显示其可以参与身体代谢, 抑制肥胖的发生, 随后又发现 Irisin 具有改善 2 型 糖尿病、代谢综合征、骨质疏松症等疾病症状的作用。同时, Irisin 对儿童青少年糖脂代谢和骨代谢具有促进作用, 但其作 用机制还存在争议。本研究综述 Irisin 在国内外儿童青少年身体代谢方面的相关报道, 为研究儿童青少年身体代谢提供理 论参考依据。