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      The role of rifaximin in the treatment and chemoprophylaxis of travelers’ diarrhea

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          Abstract

          Travelers’ diarrhea is a common illness among international travelers from developed to developing countries. Travelers’ diarrhea is caused by ingestion of contaminated food and water. Bacteria are the primary cause of travelers’ diarrhea. In most surveys, the most common diarrheal pathogen identified is enterotoxigenic Escherichia coli. There are several antimicrobial agents available for the treatment of travelers’ diarrhea including rifaximin which is approved in the United States for the treatment of travelers’ diarrhea due to noninvasive E. coli strains. In this review, we will review the most recent advances of rifaximin for the treatment and prevention of travelers’ diarrhea, with regard to its pharmacokinetics, in vitro susceptibility profile, and efficacy and safety data from clinical trials.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2009
          2009
          2 November 2009
          : 5
          : 841-848
          Affiliations
          [1 ]Baylor College of Medicine, Houston, TX, USA;
          [2 ]University of Texas at Houston School of Public Health, Houston, TX, USA;
          [3 ]Veterans Affairs Medical Center, East Orange, NJ, USA
          Author notes
          Correspondence: David Huang, 320 East 46th Street, 23C, New York, NY 10017, USA, Tel +1 347 637 0954, Fax +1 646 348 8494, Email dhuang82@ 123456hotmail.com
          Article
          tcrm-5-841
          2773752
          19898648
          © 2009 Koo et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Review

          Medicine

          treatment, prevention, travelers’ diarrhea, rifaximin

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