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      Higher adrenomedullin levels during implantation are associated with successful pregnancy

      * , 1 , 2 , 2 , 3
      Future Science OA
      Future Science Ltd
      in vitro fertilization, adrenomedullin, embryo, embryo transfer, endometrium, implantation, infertility, placentation, pregnancy, serum

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          To determine how the adrenomedullin (ADM) level in a woman’s serum on the day of embryo transfer affects pregnancy results.

          Materials & Methods:

          Women who had undergone frozen embryo transfer between July 2018 and February 2019 were prospectively included in the study. The relation between the level of ADM and pregnancy result was examined after taking a sample of serum from each patients on the same day as the transfer.


          The results revealed that the ADM levels in patients who became pregnant were higher, but not to a statistically significant level.


          Adrenomedullin is an important molecule for human embryo implantation.

          Lay abstract

          Implantation is the most important stage of in vitro fertilization. Despite a great many improvements in in vitro fertilization, the mechanism behind embryonic implantation remains a challenge. Adrenomedullin (ADM) is one of the molecules that has been researched to determine its role in implantation; building on this work, the present study aimed to show the effect of ADM on implantation. This study makes a crucial contribution to the literature, providing more information about how ADM affects the implantation process in humans.

          Most cited references16

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          Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis.

          The study aimed to investigate key intrafollicular prognostic factors among various cytokines and angiogenic molecules for prediction of mature oocytes and good-quality embryos in women with endometriosis undergoing in vitro fertilization (IVF).
            • Record: found
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            Is Open Access

            Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models

            Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.
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              Adrenomedullin gene dosage correlates with tumor and lymph node lymphangiogenesis.

              Adrenomedullin (AM) is a potent lymphangiogenic factor that promotes lymphatic endothelial cell (LEC) proliferation through a pharmacologically tractable G-protein-coupled receptor. Numerous types of human cancers have increased levels of AM; however, the functional consequences of this fact have not been characterized. Therefore, we evaluated whether modulating adrenomedullin (Adm) gene dosage within tumor cells affects lymphangiogenesis. Murine Lewis lung carcinoma (LLC) cells that overexpress or underexpress Adm were injected subcutaneously into C57BL/6 mice, and tumors were evaluated for growth and vascularization. A dosage range from ∼10 to 200% of wild-type Adm expression did not affect LLC proliferation in vitro or in vivo, nor did it affect angiogenesis. Notably, the dosage of Adm markedly and significantly influenced tumor lymphangiogenesis. Reduced Adm expression in tumors decreased the proliferation of LECs and the number of lymphatic vessels, while elevated tumor Adm expression led to enlarged lymphatic vessels. Moreover, overexpression of Adm in tumors induced sentinel lymph node lymphangiogenesis and led to an increased incidence of Ki67-positive foci within the lung. These data show that tumor-secreted AM is a critical factor for driving both tumor and lymph node lymphangiogenesis. Thus, pharmacological targeting of AM signaling may provide a new avenue for inhibition of tumor lymphangiogenesis.

                Author and article information

                Future Sci OA
                Future Sci OA
                Future Science OA
                Future Science Ltd (London, UK )
                14 January 2020
                February 2020
                14 January 2020
                : 6
                : 2
                : FSO453
                [1 ]Department of Obstetrics & Gynecology, Amasya University Research Hospital, Amasya, Turkey
                [2 ]Ondokuz Mayis University IVF Center, Ondokuz Mayis University Hospital, Samsun, Turkey
                [3 ]Department of Biochemistry, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
                Author notes
                [* ]Author for correspondence: Tel.: +90505 695 9485; parpi2300@ 123456hotmail.com
                Author information
                © 2020 Pervin Karli

                This work is licensed under the Creative Commons Attribution 4.0 License

                : 26 November 2019
                : 23 December 2019
                : 14 January 2020
                Research Article

                in vitro fertilization,adrenomedullin,embryo,embryo transfer,endometrium,implantation,infertility,placentation,pregnancy,serum


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