Higher adrenomedullin levels during implantation are associated with successful pregnancy

Abstract

Aim:

To determine how the adrenomedullin (ADM) level in a woman’s serum on the day of embryo transfer affects pregnancy results.

Materials & Methods:

Women who had undergone frozen embryo transfer between July 2018 and February 2019 were prospectively included in the study. The relation between the level of ADM and pregnancy result was examined after taking a sample of serum from each patients on the same day as the transfer.

Results:

The results revealed that the ADM levels in patients who became pregnant were higher, but not to a statistically significant level.

Conclusion:

Adrenomedullin is an important molecule for human embryo implantation.

Lay abstract

Implantation is the most important stage of in vitro fertilization. Despite a great many improvements in in vitro fertilization, the mechanism behind embryonic implantation remains a challenge. Adrenomedullin (ADM) is one of the molecules that has been researched to determine its role in implantation; building on this work, the present study aimed to show the effect of ADM on implantation. This study makes a crucial contribution to the literature, providing more information about how ADM affects the implantation process in humans.