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      The Diagnostic Value of Serum Ferritin for Telogen Effluvium: A Cross-Sectional Comparative Study

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          Abstract

          Purpose

          This study aimed to explore the relationship between serum ferritin levels and telogen effluvium.

          Patients and Methods

          A total of 193 telogen effluvium patients and 104 female androgenetic alopecia patients were included. We collected the test result of serum ferritin levels, compared with the results of 183 healthy subjects. Receiver Operator Characteristic curves were generated to assess the potential diagnostic value of serum ferritin in telogen effluvium patients.

          Results

          The serum ferritin in telogen effluvium patients were significantly lower than that in the healthy control group (P = 0.000) or female androgenetic alopecia patients (P =0.000). Patients with lower serum ferritin levels got high odds to have telogen effluvium. The areas under the Receiver Operator Characteristic curve of serum ferritin levels were 0.735 and 0.645 for distinguishing telogen effluvium patients from healthy control subjects or female androgenetic alopecia patients.

          Conclusion

          Serum ferritin could be a potential biomarker for clinical diagnosis of telogen effluvium.

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          Most cited references15

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          Serum ferritin: Past, present and future.

          Yan-Wei Wang, Katy Coffman, Suzy Torti … (2010)
          Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases. In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool. Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer. Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights. Copyright 2010 Elsevier B.V. All rights reserved.
          Article 0 comments Cited 206 times – based on 0 reviews     Review now
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            Iron deficiency

            Clara Camaschella (2019)
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              The Role of Vitamins and Minerals in Hair Loss: A Review

              Hind M. Almohanna, Azhar A. Ahmed, John P Tsatalis … (2018)
              People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing. Management of alopecia is an essential aspect of clinical dermatology given the prevalence of hair loss and its significant impact on patients’ quality of life. The role of nutrition and diet in treating hair loss represents a dynamic and growing area of inquiry. In this review we summarize the role of vitamins and minerals, such as vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, iron, selenium, and zinc, in non-scarring alopecia. A broad literature search of PubMed and Google Scholar was performed in July 2018 to compile published articles that study the relationship between vitamins and minerals, and hair loss. Micronutrients such as vitamins and minerals play an important, but not entirely clear role in normal hair follicle development and immune cell function. Deficiency of such micronutrients may represent a modifiable risk factor associated with the development, prevention, and treatment of alopecia. Given the role of vitamins and minerals in the hair cycle and immune defense mechanism, large double-blind placebo-controlled trials are required to determine the effect of specific micronutrient supplementation on hair growth in those with both micronutrient deficiency and non-scarring alopecia to establish any association between hair loss and such micronutrient deficiency. Plain Language Summary: Plain language summary available for this article.
              Article 0 comments Cited 42 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Clin Cosmet Investig Dermatol
                Journal ID (iso-abbrev): Clin Cosmet Investig Dermatol
                Journal ID (publisher-id): ccid
                Journal ID (pmc): ccid
                Title: Clinical, Cosmetic and Investigational Dermatology
                Publisher: Dove
                ISSN (Electronic): 1178-7015
                Publication date (Electronic): 10 February 2021
                Publication date Collection: 2021
                Volume: 14
                Pages: 137-141
                Affiliations
                [1 ]School of Clinical Medicine, Beijing University of Chinese Medicine , Beijing, People’s Republic of China
                [2 ]Department of Dermatology, China-Japan Friendship Hospital , Beijing, People’s Republic of China
                [3 ]Department of Clinical Laboratory, China-Japan Friendship Hospital , Beijing, People’s Republic of China
                Author notes
                Correspondence: Dingquan Yang Department of Dermatology, China-Japan Friendship Hospital , Beijing, People’s Republic of ChinaTel +86 13901218671 Email ydqlx@163.com
                Author information
                http://orcid.org/0000-0002-8466-6971
                http://orcid.org/0000-0003-0122-3399
                Article
                Publisher ID: 291170
                DOI: 10.2147/CCID.S291170
                PMC ID: 7882421
                SO-VID: da77ea35-8d90-448a-840a-62bf7e66767b
                Copyright © © 2021 Cheng et al.
                License:

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                Date received : 16 November 2020
                Date accepted : 18 January 2021
                Page count
                Figures: 2, Tables: 7, References: 15, Pages: 5
                Funding
                Funded by: National Natural Science Foundation of China, open-funder-registry 10.13039/501100001809;
                This study was supported by the National Natural Science Foundation of China (No. 81973691).
                Categories
                Subject: Original Research

                ScienceOpen disciplines: Dermatology
                Keywords: serum ferritin,telogen effluvium,female androgenetic alopecia,roc curve
                Data availability:
                ScienceOpen disciplines: Dermatology
                Keywords: serum ferritin, telogen effluvium, female androgenetic alopecia, roc curve

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