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      Melatonin Given in the Morning Prevents the Suppressive Action on the Reproductive System of Melatonin Given in Late Afternoon

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      , ,
      Neuroendocrinology
      S. Karger AG
      Melatonin, Luteinizing hormone, Prolactin, Estrous cycle, Uterus, Hamster

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          Abstract

          Melatonin administered to female hamsters kept under light:dark cycles of 14:10 (in hours) normally suppresses reproductive processes only if the indoleamine is administered later than 6.5 h after the beginning of the photoperiod. In the present study, we investigated the influence of morning (11.00h) injections of melatonin on the reproductive inhibitory effects of afternoon (17.00 h) melatonin injections. Adult female hamsters were exposed to light daily from 06.00 to 20.00 h. The animals were divided into the following experimental groups: group 1, injected with vehicle at both 11.00 and 17.00 h; group 2, injected with vehicle at 11.00 h and 25 μg melatonin at 17.00 h; group 3, injected with 1 mg melatonin at 11.00 h and 25 μg melatonin at 17.00 h; group 4, injected with 1 mg melatonin at 11.00 h and vehicle at 17.00 h. Control animals injected with vehicle at both 11.00 and 17.00 h had normal 4-day estrous cycles throughout the 8 weeks of the experiment. 100% of the animals injected with vehicle in the morning and melatonin in the afternoon became acyclic within 7 weeks. However, if the afternoon injections of melatonin were preceded by morning injections of the indoleamine, the animals continued to exhibit normal estrous cycles. Also, hamsters injected with melatonin at 11.00 h and vehicle at 15.00 h had normal estrous cycles throughout the study. At the conclusion of the experiment, the uterine weights and plasma prolactin levels in the animals that received vehicle at 11.00 h and melatonin at 17.00 h were depressed compared to those in the vehicle-vehicle injected controls. Again, the morning injections of melatonin prevented the afternoon injections of melatonin from decreasing either the uterine weights or the plasma prolactin levels. It is concluded that the morning injections of melatonin either down-regulated the melatonin receptors or decreased their number and thereby rendered afternoon injections of melatonin incapable of inhibiting reproductive processes.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1980
          1980
          26 March 2008
          : 31
          : 2
          : 129-132
          Affiliations
          Department of Anatomy, University of Texas, Health Science Center at San Antonio, San Antonio, Tex.
          Article
          123063 Neuroendocrinology 1980;31:129–132
          10.1159/000123063
          7190229
          da7d274e-370d-4c64-9da8-b37ee98c8a42
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 05 December 1979
          : 15 January 1980
          Page count
          Pages: 4
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Melatonin,Uterus,Hamster,Prolactin,Luteinizing hormone,Estrous cycle

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