29
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Dynamic circuit motifs underlying rhythmic gain control, gating and integration.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity contributes to network formation and how it relates to the computation of behaviorally relevant information has remained difficult to discern. Here we structure recent empirical advances that link synchronized activity to the activation of so-called dynamic circuit motifs. These motifs explicitly relate (1) synaptic and cellular properties of circuits to (2) identified timescales of rhythmic activation and to (3) canonical circuit computations implemented by rhythmically synchronized circuits. We survey the ubiquitous evidence of specific cell and circuit properties underlying synchronized activity across theta, alpha, beta and gamma frequency bands and show that their activation likely implements gain control, context-dependent gating and state-specific integration of synaptic inputs. This evidence gives rise to the dynamic circuit motifs hypothesis of synchronized activation states, with its core assertion that activation states are linked to uniquely identifiable local circuit structures that are recruited during the formation of functional networks to perform specific computational operations.

          Related collections

          Author and article information

          Journal
          Nat. Neurosci.
          Nature neuroscience
          Springer Nature
          1546-1726
          1097-6256
          Aug 2014
          : 17
          : 8
          Affiliations
          [1 ] 1] Department of Biology, York University, Toronto, Ontario, Canada. [2] Centre for Vision Research, York University, Toronto, Ontario, Canada.
          [2 ] 1] Division of Fundamental Neurobiology, Toronto Western Research Institute, Toronto, Ontario, Canada. [2] Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
          [3 ] 1] Brain Power, LLC, Boston, Massachusetts, USA. [2] Department of Psychology, Harvard University, Cambridge, Massachusetts, USA.
          [4 ] 1] Department of Physics, University of Washington, Seattle, Washington, USA. [2] Department of Neurosurgery, Stanford University, Stanford, California, USA.
          [5 ] Donders Institute for Brain, Behavior, and Cognition, Radboud University Nijmegen, Nijmegen, the Netherlands.
          Article
          nn.3764
          10.1038/nn.3764
          25065440
          da98307e-ecfe-4101-acc2-270fa8f8a27c
          History

          Comments

          Comment on this article