The role of thiopurines in reducing the need for surgical resection in Crohn's disease: a systematic review and meta-analysis.

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Abstract

The thiopurine (TP) analogs azathioprine and mercaptopurine have proven efficacy in inducing and maintaining clinical remission in Crohn's disease (CD). Their impact on the long-term need for surgery is uncertain since studies have reported conflicting results. The aim of this systematic review was to summarize and evaluate evidence of the published literature regarding those studies assessing the impact of TPs on the risk of first surgical resection in CD.

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Author and article information

Journal

Journal ID (iso-abbrev): Am. J. Gastroenterol.

Title: The American journal of gastroenterology

ISSN (Electronic): 1572-0241

ISSN (Print): 0002-9270

Publication date (Electronic): Jan 2014

Volume: 109

Issue: 1

Affiliations

[1 ] Department of Gastroenterology, St George's University Hospital, London, UK.

[2 ] Center for Digestive Diseases, St James's University Hospital, Leeds, UK.

[3 ] Department of Primary Care and Public Health, Imperial College, London, UK.

Article

Publisher Item ID: ajg2013402

DOI: 10.1038/ajg.2013.402

PubMed ID: 24322839

SO-VID: daa09d26-c025-4273-89f7-a3e615195530

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