Blog
About

36
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      High interstitial fluid pressure - an obstacle in cancer therapy.

      Nature reviews. Cancer

      pharmacology, Animals, Antineoplastic Agents, pharmacokinetics, Biological Transport, Bradykinin, antagonists & inhibitors, Extracellular Fluid, physiology, Humans, Hyaluronoglucosaminidase, Hydrostatic Pressure, Mice, Neoplasms, blood supply, drug therapy, physiopathology, Niacinamide, Platelet-Derived Growth Factor, Signal Transduction, drug effects, Transforming Growth Factor beta, Tumor Necrosis Factor-alpha, Vascular Endothelial Growth Factor A, Alprostadil

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

          Related collections

          Author and article information

          Journal
          15510161
          10.1038/nrc1456

          Comments

          Comment on this article