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      The epithelioid BAP1-negative and p16-positive phenotype predicts prolonged survival in pleural mesothelioma.

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          Abstract

          Mesothelioma is a relatively uncommon but highly malignant neoplasm. Most patients die of disease within 1 year of diagnosis, but some have prolonged survival. Prospective identification of these longer-term survivors may help to guide treatment. We therefore sought to investigate the role of p16 immunohistochemistry (IHC) both alone and in combination with other markers as a potential predictor of prolonged survival in mesothelioma.

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          Author and article information

          Journal
          Histopathology
          Histopathology
          Wiley
          1365-2559
          0309-0167
          Feb 2018
          : 72
          : 3
          Affiliations
          [1 ] Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia.
          [2 ] University of Sydney, Sydney, NSW, Australia.
          [3 ] Department of Anatomical Pathology, SYDPATH, St Vincent's Hospital, Darlinghurst, NSW, Australia.
          [4 ] The Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
          [5 ] Histopath Pathology, Macquarie Park, NSW, Australia.
          [6 ] NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.
          Article
          10.1111/his.13392
          28889523

          p16, BAP1, mesothelioma

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