The epithelioid BAP1-negative and p16-positive phenotype predicts prolonged survival in pleural mesothelioma.

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Abstract

Mesothelioma is a relatively uncommon but highly malignant neoplasm. Most patients die of disease within 1 year of diagnosis, but some have prolonged survival. Prospective identification of these longer-term survivors may help to guide treatment. We therefore sought to investigate the role of p16 immunohistochemistry (IHC) both alone and in combination with other markers as a potential predictor of prolonged survival in mesothelioma.

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Journal

Journal ID (iso-abbrev): Histopathology

Title: Histopathology

Publisher: Wiley

ISSN (Electronic): 1365-2559

ISSN (Print): 0309-0167

Publication date (Electronic): Feb 2018

Volume: 72

Issue: 3

Affiliations

[1 ] Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia.

[2 ] University of Sydney, Sydney, NSW, Australia.

[3 ] Department of Anatomical Pathology, SYDPATH, St Vincent's Hospital, Darlinghurst, NSW, Australia.

[4 ] The Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

[5 ] Histopath Pathology, Macquarie Park, NSW, Australia.

[6 ] NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.

Article

DOI: 10.1111/his.13392

PubMed ID: 28889523

SO-VID: dabeda54-250f-4f38-8731-eb3cd6354adb

History

Keywords: p16,BAP1,mesothelioma

Data availability:

Keywords: p16, BAP1, mesothelioma

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