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Dissecting the Genetics of Osteoporosis using Systems Approaches
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Abstract
Osteoporosis is a condition characterized by low bone mineral density and an increased
risk of fracture. Traits contributing to osteoporotic fracture are highly heritable,
indicating that a comprehensive understanding of bone requires a thorough understanding
of the genetic basis of bone traits. Towards this goal, genome-wide association studies
(GWASs) have identified over 500 loci associated with bone traits. However, few of
the responsible genes have been identified, and little is known of how these genes
work together to influence systems-level bone function. In this review, we describe
how systems genetics approaches can be used to fill these knowledge gaps.