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A Clinico-analytical Study on Seed of Wrightia antidysenterica Linn. as a Therapeutic Emetic Agent (Vamaka Yoga) in the Management of Psoriasis

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      Abstract

      Objectives:

      Wrightia antidysenterica Linn. (WA) is male variety Kutaja stated to be potent therapeutic emetic agent in skin disorders. Expulsion of doshas through oral route is termed as Vamana Karma (VK) (therapeutic emesis). However, so far, its utility for Vamana is not explored in detail, therefore there is a need to revalidate the utility of WA for Vamana. Hence, the above study was conducted to ascertain the efficacy as a therapeutic emetic agent (vamaka yoga) in the management of psoriasis along with quality control and standardization of this herb.

      Materials and Methods:

      The drug was standardized as per analytical procedures in Pharmacopeias. Thirty patients of psoriasis fulfilling inclusion criteria were taken for the study and Vamana with WA was conducted. Criteria were prepared to assess the signs and Symptoms of psoriasis. VK was assessed using the classical Lakshanas (features) such as Anthiki shudhi (Ending symptoms of emesis), Vaigiki shudhi (features of vomiting bouts), Maniki shudhi (Quantitative and qualitative purification), complications.

      Result:

      VK with WA showed significant relief in parameters of psoriasis such as scaling, itching, candle grease sign ( P < 0.001), and psoriasis area and severity index score ( P = 0.001). In VK with WA, mean number of Vegas (vomiting bouts) was 6.91. 66% patients showing quantitative purification between 301 and 600 ml. 73.33% showed all Symptoms of purification. 73.33% patients showed Kaphanta vamana (Moderate expulsion of desire humor). In the level of biopurification, 66.66% patients showed moderated purification. No complication was noted with moderate drug palatability.

      Conclusion:

      Pharmacopeial analytical study showed its standardized values for testing the drug used for the study. It is proved as potent therapeutic emetic agent with no complication showed its clinical benefits over skin disorder like psoriasis.

      SUMMARY

      • Seeds of Wrightia antidysenterica (WA) Linn. free from any foreign matter were selected for the study. Loss on drying revealed 6.535% moisture content; total ash indicating of total inorganic content was found to be 5.12%; acid insoluble ash is the acid insoluble part of total ash, mainly silica, WA showed 0.393% acid insoluble ash; ethanol and water soluble extractive is indicative of percentage active constituents were found to be 25.66 and 20.854%, respectively. High-performance thin layer chromatography fingerprinting profiles of WA under 254 nm showed the presence of 7 spots (all in green) at R f values ranging from 0.21 to 0.88. Under 366 nm there were 4 prominent spots (all in fluorescent) at R f 0.49 to 0.82 and, when scanned under white light 620 nm following derivatization with vanillin sulfuric acid 6 spots (in different colors) were evident at R f 0.28 to 0.58. Among these spot with R f of 0.58 was common when visualized under all the three methods. R f values by densitometric scan of WA showed 12 peaks at 254 nm and 5 peaks at 366 nm. However, in clinical trial, it was found to be a potent emetic agent without any complication.

      Abbreviations Used: WA: Wrightia antidysenterica; Linn.; VK: Vamana karma; BT: Before treatment; FP: Freidman's P value; CHS: Chi-square value; NR: Negative ranks; PR: Positive ranks; N: Sample number, AS: Austipz sign; CG: Candle grease test; SSL: Samyak Snigdha Lakshana

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      Most cited references 20

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      Anonymous. the Ayurvedic Pharmacopea of India

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        WHO. Quality Control Methods for Medicinal Plant Material

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          Is Open Access

          GENETICS OF PSORIASIS AND PSORIATIC ARTHRITIS

          It is well established that psoriasis and psoriatic arthritis (PsA) have a strong genetic component. Recent advances in genetics have confirmed previous associations and new loci have been discovered. However, these loci do not fully account for the high heritability of psoriasis and PsA and therefore many genetic as well as environmental factors remain to be identified. This paper reviews the current status of genetic studies in psoriasis and PsA.
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            Author and article information

            Affiliations
            Department of Panchakarma, SDM College of Ayurveda and Hospital, Hassan, Karnataka, India
            [1 ]SDM Center for Research in Ayurveda and Allied Sciences, Udupi, Karnataka, India
            Author notes
            Correspondence: Dr. Nirupam Bhattacharyya, House Number 42, LNB Path, Hatigaon Road, District Kamrup (Metro), Guwahati - 781 038, Assam, India. E-mail: drniru9999@ 123456gmail.com
            Journal
            Pharmacognosy Res
            Pharmacognosy Res
            PR
            Pharmacognosy Research
            Medknow Publications & Media Pvt Ltd (India )
            0976-4836
            0974-8490
            March 2016
            : 8
            : Suppl 1
            : S19-S25
            27114687
            4821102
            PR-8-19
            10.4103/0974-8490.178641
            Copyright: © 2016 Pharmacognosy Research

            This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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