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      Effect of Excitatory Amino Acids on Serum TSH and Thyroid Hormone Levels in Freely Moving Rats

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          The actions of glutamate (L-Glu), and glutamate receptor agonists on serum thyroid hormones (T4 and T3) and TSH levels have been studied in conscious and freely moving adult male rats. The excitatory amino acids (EAA), L-Glu, N-methyl- D-aspartate (NMDA), kainic acid (KA) and domoic acid (Dom) were administered intraperitoneally. Blood samples were collected through a cannula implanted in the rats jugular 0–60 min after injection. Thyroid hormone concentrations were measured by enzyme immunoassay, and thyrotrophin (TSH) concentrations were determined by radioimmunoassay. The results showed that L-Glu (20 and 25 mg/kg) and NMDA (25 mg/kg) increased serum thyroxine (T4), triiodothyronine (T3) and TSH concentrations. Serum thyroid hormone levels increased 30 min after treatment, while serum TSH levels increased 5 min after i.p. administration, in both cases serum levels remained elevated during one hour. Injection of the non-NMDA glutamatergic agonists KA (30 mg/kg) and Dom (1 mg/kg) produced an increase in serum thyroid hormones and TSH levels. These results suggest the importance of EAAs in the regulation of hormone secretion from the pituitary-thyroid axis, as well as the importance of the NMDA and non-NMDA receptors in this stimulatory effect.

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          Acute glutamate-induced elevations in serum testosterone and luteinizing hormone

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            Differential control of glucoregulatory hormone response and glucose metabolism by NMDA and kainate

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              • Abstract: not found
              • Article: not found

              Neurotransmitter control of hypothalamic-pituitary-thyroid functions in rats


                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                09 March 2001
                : 54
                : 2
                : 78-83
                Departamento de Biología Funcional y Ciencias de la Salud, Area de Fisiología, Facultad de Ciencias, Universidad de Vigo, Spain
                53236 Horm Res 2000;54:78–83
                © 2001 S. Karger AG, Basel

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                Page count
                Figures: 5, References: 29, Pages: 6
                Original Paper


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