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      Prophylactic inferior vena cava filter placement prior to lumbar surgery in morbidly obese patients: Two-case study and literature review

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          Abstract

          Background:

          Preoperative “prophylactic” placement of inferior vena cava (IVC) filters in morbidly obese patients (e.g., body mass index [BMI] >40 or BMI over 35 with hypertension/diabetes) undergoing multilevel decompressive lumbar laminectomies may reduce the risk of postoperative pulmonary embolism (PE), and death.

          Methods:

          Two patients, ages 69 and 68, with morbid obesity (BMI's of 40.4 and 37.5 both with hypertension and diabetes), received prophylactic IVC filters prior to L1–S1 laminectomies. Intraoperatively and postoperatively, both received alternating compression stocking prophylaxis, and received subcutaneous heparin 5000 U q12 h 48 h after surgery until discharge; none developed deep venous thrombosis (DVT) or PE, and both filters were uneventfully removed within 3 postoperative months.

          Results:

          The spinal surgical literature largely supports the placement of IVC filters for major risk factors; obesity (BMI >40), a history of DVT/PE, cancer, fusions, hypercoagulation syndromes, pulmonary/circulatory disorders, preoperative/postoperative immobility, staged procedures (five spinal levels), combined anterior-posterior surgery, iliocaval manipulation, age >80, and prolonged surgery (e.g., >261 min vs. >8 h). Although the safety and efficacy of prophylactic IVC filters for spine surgery in patients with morbidly obesity are well substantiated, those for bariatric patients are less clear.

          Conclusions:

          Prophylactic IVC filters were successfully placed/retrieved in 2 morbidly obese patients, ages 68 and 69, undergoing L1–S1 lumbar decompressions. Although the spine surgery literature documents the safety/efficacy of prophylactic IVC filters in patients with morbid obesity, the bariatric literature still has major concerns.

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          Most cited references18

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          Decreased incidence of venous thromboembolism after spine surgery with early multimodal prophylaxis: Clinical article.

          Venous thromboembolism (VTE) represents a significant complication after spine surgery, with reported rates as high as 2%-4%. Published institutional practices for VTE prophylaxis are highly variable. In 2008, the authors implemented a departmental protocol for early VTE prophylaxis consisting of combined compressive devices and subcutaneous heparin initiated either preoperatively or on the same day of surgery. In this study, the authors compared the incidence of VTE in spine surgery patients before and after implementing this protocol. An institutional review board-approved retrospective review of outcomes in patients undergoing spine surgery 2 years before protocol implementation (representing the preprotocol group) and of outcomes in patients treated 2 years thereafter (the postprotocol group) was conducted. Inclusion criteria were that patients were 18 years or older and had been admitted for 1 or more days. Before 2008 (preprotocol), VTE prophylaxis was variable and provider dependent without any uniform protocol. Since 2008 (postprotocol), a new VTE-prophylaxis protocol was administered, starting either preoperatively or on the same day of surgery and continuing throughout hospitalization. The new protocol consisted of 5000 U heparin administered subcutaneously 3 times daily, except in patients older than 75 years or weighing less than 50 kg, who received this dose twice daily. All patients also received sequential compression devices (SCDs). The incidence of VTE in the 2 protocol phases was identified by codes of the International Classification of Diseases, Ninth Revision (ICD-9) codes for deep vein thrombosis (DVT) and pulmonary embolus (PE). Bleeding complications arising from anticoagulation treatments were evaluated by the Current Procedural Terminology (CPT) code for postoperative epidural hematoma (EDH) requiring evacuation. In total, 941 patients in the preprotocol group met the inclusion criteria: 25 had DVT (2.7%), 6 had PE (0.6%), and 6 had postoperative EDH (0.6%). In the postprotocol group, 992 patients met the criteria: 10 had DVT (1.0%), 5 had PE (0.5%), and 4 had postoperative EDH (0.4%). This reduction in DVT after the protocol's implementation was statistically significant (p = 0.009). Despite early aggressive prophylaxis, the incidence of postoperative EDH did not increase and compared favorably to the published literature. At a high-volume tertiary center, an aggressive protocol for early VTE prophylaxis after spine surgery decreases VTE incidence without increasing morbidity.
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            Surgeon practices regarding postoperative thromboembolic prophylaxis after high-risk spinal surgery.

            Survey study. To assess a sample of spine surgeons' current practices of thromboembolic prophylaxis after high-risk surgery for tumors and trauma. Although chemoprophylaxis for thromboembolic events is not routinely used after elective spinal surgery, it is more widely recommended in high-risk patients after spine surgery for trauma or tumors. In these high-risk cases, surgeons must decide what method(s) of prophylaxis to use and when it can be safely initiated. Unfortunately, there are limited data evaluating the efficacy or safety of different prophylaxis protocols after high-risk spinal surgery; as a result there are no accepted treatment guidelines concerning this issue. To the authors' knowledge, no previous study examining practices of thromboembolic prophylaxis after high-risk spinal surgery has been published. One hundred ninety-three orthopaedic and neurosurgical spine surgeons with established clinical interest and volume in spine trauma and/or spine tumor surgery were invited by email to complete an on-line questionnaire. Ten questions focused on varying issues that included the perceived risk of deep venous thrombosis (DVT), pulmonary embolism (PE), postoperative epidural hematoma, preferred chemoprophylactic agents, the safe time point for initiation of chemoprophylaxis, and use of inferior vena cava (IVC) filters. Ninety-four surgeons completed the questionnaire, which represented a 49% response rate. Regarding a safe time point to start chemoprophylaxis, the most common response was 48 hours after surgery (21 of 94, 22%). However, individual responses varied widely: 15% chose 24 hours, 13% chose 72 hours, 12% chose less than 24 hours, and 10% chose 96 hours. Some indicated they would start chemoprophylaxis before surgery, whereas others responded they would never use it. Sixty-three percent (59 of 94) stated that they based this decision on personal experience over evidence-based review of the literature. A majority of surgeons selected low-molecular-weight heparin as their agent of choice (54 of 94, 58%). Respondents most commonly (44 of 93, 47%) felt that the risk of clinically relevant postoperative epidural hematoma was between 1% and 5%; 29% (27 of 93) felt the risk was less than 1%; and 17% (16 of 93) felt it was as high as 5% to 10%. Those who felt the risk of epidural hematoma to be lower than 5% tended to initiate chemoprophylaxis earlier than those who estimated the risk to be higher than 5%. Thirty-seven percent (34 of 93) felt the perceived risk for a DVT was 1% to 5%; 25% (23 of 94) felt it was 5% to 10%; and 16% (15 of 93) felt it was less than 1%. Those who estimated the risk of DVT to be higher tended to initiate therapy earlier than groups that estimated the risk to be lower. Although the decision to use an IVC filter varied considerably, there was a clear trend towards having the filter placed before surgery (60 of 78, 77%). These data are the first to demonstrate the wide variability of surgeons' practices regarding thromboembolic prophylaxis in high-risk spine surgery patients. This variability is likely a symptom of the glaring paucity of scientific evidence concerning the risk for symptomatic epidural hematoma, DVT, and PE and the efficacy and safety of specific chemoprophylactic protocols after spine surgery. This study highlights the need for more rigorous prospective evaluation of thromboembolic risk after spinal surgery and, subsequently, the efficacy and safety of currently available thromboembolic prophylaxis protocols.
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              Risk Factors for Venous Thromboembolism After Spine Surgery

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                Author and article information

                Contributors
                Journal
                Surg Neurol Int
                Surg Neurol Int
                SNI
                Surgical Neurology International
                Medknow Publications & Media Pvt Ltd (India )
                2229-5097
                2152-7806
                2015
                08 October 2015
                : 6
                : Suppl 19 , SNI: Spine, a supplement to Surgical Neurology International
                : S469-S474
                Affiliations
                [1]Department of Neuroscience, Winthrop University Hospital, Mineola, New York, USA
                Author notes
                [* ]Corresponding author
                Article
                SNI-6-469
                10.4103/2152-7806.166877
                4617024
                daea693a-60b0-4956-8f16-054a0ffc5cd1
                Copyright: © 2015 Surgical Neurology International

                This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

                History
                : 04 July 2015
                : 13 July 2015
                Categories
                Surgical Neurology International: Spine

                Surgery
                bariatric surgery,deep venous thrombosis,efficacy,inferior vena cava filter,morbidly obese patients,mortality,prophylaxis,pulmonary embolism,safety,spine surgery

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