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      Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.

      Science (New York, N.Y.)

      Animals, Candida albicans, pathogenicity, physiology, Candidiasis, microbiology, Candidiasis, Oral, Cell Adhesion, Epithelial Cells, enzymology, Fungal Proteins, GTP Phosphohydrolases, metabolism, GTP-Binding Proteins, Genes, Fungal, Humans, Membrane Glycoproteins, genetics, Mice, Mice, Inbred CBA, Mouth Mucosa, Recombinant Proteins, Transglutaminases

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          Abstract

          The pathogenesis of candidiasis involves invasion of host tissues by filamentous forms of the opportunistic yeast Candida albicans. Morphology-specific gene products may confer proinvasive properties. A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases. Candida albicans strains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice. This represents a paradigm for microbial adhesion that implicates essential host enzymes.

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          10066176

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