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      Connexin32 is a myelin-related protein in the PNS and CNS

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          Abstract

          We have examined the expression of a gap junction protein, connexin32 (Cx32), in Schwann cells and oligodendrocytes. In peripheral nerve, Cx32 is found in the paranodal myelin loops and Schmidt-Lanterman incisures of myelinating Schwann cells, and the levels of Cx32 protein and mRNA change in parallel with those of other myelin-related genes during development, Wallerian degeneration, and axonal regeneration. In the central nervous system, Cx32 is found in oligodendrocytes and their processes, but not in compact myelin, and the levels of Cx32 protein and mRNA increase during development in parallel with those of the other myelin genes. Thus, Cx32 is expressed as part of the myelinating phenotype of both Schwann cells and oligodendrocytes, indicating that this gap junction protein plays in important role in the biology of myelin-forming cells.

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          Author and article information

          Journal
          J Neurosci
          J. Neurosci
          jneuro
          The Journal of Neuroscience
          Society for Neuroscience
          0270-6474
          1529-2401
          1 December 1995
          : 15
          : 12
          : 8281-8294
          Affiliations
          Department of Neurology, University of Pennsylvania, Philadelphia 19104– 6146, USA.
          Article
          PMC6577923 PMC6577923 6577923 jneuro;15/12/8281
          10.1523/JNEUROSCI.15-12-08281.1995
          6577923
          8613761
          daf10722-9cf8-40ee-91b2-10bad91a4da3
          © 1995 by Society for Neuroscience
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          15/12/8281
          8281

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