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      Mutations in GNA11 in uveal melanoma.

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          Abstract

          Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          1533-4406
          0028-4793
          Dec 02 2010
          : 363
          : 23
          Affiliations
          [1 ] Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
          Article
          NIHMS257039
          10.1056/NEJMoa1000584
          3107972
          21083380
          daf1cadb-8c72-40cf-bcc0-7c6da77fed34
          History

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