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Mutations in GNA11 in uveal melanoma.
Catherine D Van Raamsdonk
1 ,
Klaus G Griewank ,
Michelle B Crosby ,
Maria C Garrido ,
Swapna Vemula ,
Thomas Wiesner ,
Anna C Obenauf ,
Werner Wackernagel ,
Gary Green ,
Nancy Bouvier ,
M Mert Sozen ,
Gail Baimukanova ,
Ritu Roy ,
Adriana Heguy ,
Igor Dolgalev ,
Raya Khanin ,
Klaus Busam ,
Michael R Speicher ,
Joan O'Brien ,
Boris C Bastian
Dec 02 2010
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Abstract
Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas.