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      Photosensory Properties of the Pineal Organ. Microiontophoretic Application of Excitatory Amino Acids onto Pineal Neurons

      ,

      Ophthalmic Research

      S. Karger AG

      Achromatic response, Frog, Pineal organ, Microiontophoresis, Neurotransmitter, Spontaneous activity

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          Abstract

          Extracellular recordings were performed on electrophysiologically identified achromatic neurons of the photosensitive pineal organ of the frog. The effects of iontophoretically applied aspartate and glutamate as well as one aspartate antagonist ( D-α-aminoadipate) were observed on spontaneous activity and light-evoked responses of pineal neurons. Aspartate and glutamate showed a powerful excitatory effect on achromatic neurons. The effect was dose-related and reversible. D-α-Aminoadipate substantially diminished the excitatory aspartate effect. The changes observed in the ganglion cell responses after application of the drugs are discussed in light of the possible neuronal circuitry of the pineal organ.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          978-3-8055-3869-5
          978-3-318-00276-8
          0030-3747
          1423-0259
          1984
          1984
          04 December 2009
          : 16
          : 1-2
          : 114-118
          Affiliations
          Max-Planck-Institute for Physiological and Clinical Research, W. G. Kerckhoff Institute, Bad Nauheim, FRG
          Article
          265304 Ophthalmic Res 1984;16:114–118
          10.1159/000265304
          6610150
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Extraocular Light Reception: Function

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