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IL-6 and APPs: anti-inflammatory and immunosuppressive mediators
September 1997
September 1997
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Abstract
Acute inflammation is accompanied by changes in the concentrations of acute phase
proteins (APPs). While much is known about the cytokines involved in the initiation
of inflammation, less is known about the mediators involved in its resolution. Recent
data suggest that interleukin 6 (IL-6) and IL-6-regulated APPs are anti-inflammatory
and immuno-suppressive, and may negatively regulate the acute phase response.