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      Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships

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          Abstract

          We argue that the fragility of contemporary marriages—and the corresponding high rates of divorce—can be explained (in large part) by a three-part mismatch: between our relationship values, our evolved psychobiological natures, and our modern social, physical, and technological environment. “Love drugs” could help address this mismatch by boosting our psychobiologies while keeping our values and our environment intact. While individual couples should be free to use pharmacological interventions to sustain and improve their romantic connection, we suggest that they may have an obligation to do so as well, in certain cases. Specifically, we argue that couples with offspring may have a special responsibility to enhance their relationships for the sake of their children. We outline an evolutionarily informed research program for identifying promising biomedical enhancements of love and commitment.

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          Most cited references47

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          Oxytocin modulates neural circuitry for social cognition and fear in humans.

          In non-human mammals, the neuropeptide oxytocin is a key mediator of complex emotional and social behaviors, including attachment, social recognition, and aggression. Oxytocin reduces anxiety and impacts on fear conditioning and extinction. Recently, oxytocin administration in humans was shown to increase trust, suggesting involvement of the amygdala, a central component of the neurocircuitry of fear and social cognition that has been linked to trust and highly expresses oxytocin receptors in many mammals. However, no human data on the effects of this peptide on brain function were available. Here, we show that human amygdala function is strongly modulated by oxytocin. We used functional magnetic resonance imaging to image amygdala activation by fear-inducing visual stimuli in 15 healthy males after double-blind crossover intranasal application of placebo or oxytocin. Compared with placebo, oxytocin potently reduced activation of the amygdala and reduced coupling of the amygdala to brainstem regions implicated in autonomic and behavioral manifestations of fear. Our results indicate a neural mechanism for the effects of oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
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            Oxytocin improves "mind-reading" in humans.

            The ability to "read the mind" of other individuals, that is, to infer their mental state by interpreting subtle social cues, is indispensable in human social interaction. The neuropeptide oxytocin plays a central role in social approach behavior in nonhuman mammals. In a double-blind, placebo-controlled, within-subject design, 30 healthy male volunteers were tested for their ability to infer the affective mental state of others using the Reading the Mind in the Eyes Test (RMET) after intranasal administration of 24 IU oxytocin. Oxytocin improved performance on the RMET compared with placebo. This effect was pronounced for difficult compared with easy items. Our data suggest that oxytocin improves the ability to infer the mental state of others from social cues of the eye region. Oxytocin might play a role in the pathogenesis of autism spectrum disorder, which is characterized by severe social impairment.
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              Evolutionary Psychology: A New Paradigm for Psychological Science

              David Buss (2009)
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                Author and article information

                Contributors
                brian.earp@gmail.com
                Journal
                Philos Technol
                Philos Technol
                Philosophy & Technology
                Springer Netherlands (Dordrecht )
                2210-5433
                2210-5441
                5 July 2012
                5 July 2012
                December 2012
                : 25
                : 4
                : 561-587
                Affiliations
                Oxford Uehiro Centre for Practical Ethics, University of Oxford, Suite 8, Littlegate House, St Ebbes Street, Oxford, OX1 1PT UK
                Article
                81
                10.1007/s13347-012-0081-8
                3510696
                23226627
                db24c9f0-1578-4c57-9b94-ec20c0cd1821
                © The Author(s) 2012
                History
                : 7 March 2012
                : 11 June 2012
                Categories
                Special Issue
                Custom metadata
                © Springer Science+Business Media Dordrecht 2012

                Philosophy of science
                neuroenhancement,love drugs,evolution,marital autonomy,default natural ethics,marriage,values,oxytocin

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