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      Introduction of genes via sonoporation and electroporation.

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          Abstract

          Gene therapy delivery using viral vectors has demonstrated efficient transfection but has safety issues. The need for safer yet effective delivery systems has led to the active development of non-viral techniques. In this chapter, we will discuss two evolving techniques - sonoporation with microbubble contrast agents and electroporation with focus on their basic principle, parameters affecting delivery efficiency, current evolving techniques and future prospects.

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          Author and article information

          Journal
          Adv. Exp. Med. Biol.
          Advances in experimental medicine and biology
          Springer Nature
          0065-2598
          0065-2598
          2014
          : 818
          Affiliations
          [1 ] Imperial College London, Hammersmith Hospital, London, UK.
          Article
          10.1007/978-1-4471-6458-6_12
          25001540
          db26ca4b-298c-478e-adab-38d2ae06aacb
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