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      A receptor in pituitary and hypothalamus that functions in growth hormone release.

      Science (New York, N.Y.)

      Amino Acid Sequence, Animals, Base Sequence, Cell Line, Codon, DNA, Complementary, genetics, GTP-Binding Proteins, metabolism, Growth Hormone, secretion, Hormones, Humans, Hypothalamus, Middle, chemistry, Indoles, pharmacology, Macaca mulatta, Molecular Sequence Data, Oligopeptides, Pituitary Gland, RNA, Complementary, Rats, Receptors, Cell Surface, analysis, Receptors, G-Protein-Coupled, Receptors, Ghrelin, Spiro Compounds, Swine

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          Abstract

          Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.

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          8688086

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