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      Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

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          Abstract

          Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns.

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          Most cited references191

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          Carbon nanotubes: present and future commercial applications.

          Worldwide commercial interest in carbon nanotubes (CNTs) is reflected in a production capacity that presently exceeds several thousand tons per year. Currently, bulk CNT powders are incorporated in diverse commercial products ranging from rechargeable batteries, automotive parts, and sporting goods to boat hulls and water filters. Advances in CNT synthesis, purification, and chemical modification are enabling integration of CNTs in thin-film electronics and large-area coatings. Although not yet providing compelling mechanical strength or electrical or thermal conductivities for many applications, CNT yarns and sheets already have promising performance for applications including supercapacitors, actuators, and lightweight electromagnetic shields.
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            Thermal conductivity of carbon nanotubes and their polymer nanocomposites: A review

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              High Weight Fraction Surfactant Solubilization of Single-Wall Carbon Nanotubes in Water

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                Author and article information

                Journal
                Nanomaterials (Basel)
                Nanomaterials (Basel)
                nanomaterials
                Nanomaterials
                MDPI
                2079-4991
                18 July 2017
                July 2017
                : 7
                : 7
                : 186
                Affiliations
                [1 ]Chirality Program, Biomedical Science, University of Canberra, Bruce, Australian Capital Territory (ACT) 2617, Australia; Ayman.Hemasa@ 123456canberra.edu.au
                [2 ]Collaborative Research in Bioactives and Biomarkers Group (CRIBB), University of Canberra, Bruce, Australian Capital Territory (ACT) 2617, Australia; Nenad.Naumovski@ 123456canberra.edu.au
                [3 ]Ecochemistry Laboratory, Institute for Applied Ecology, University of Canberra, Bruce, Australian Capital Territory (ACT) 2617, Australia; Bill.Maher@ 123456canberra.edu.au
                Author notes
                [* ]Correspondence: ashraf.ghanem@ 123456canberra.edu.au ; Tel./Fax: +61-02-6201-2089
                Author information
                https://orcid.org/0000-0002-2841-4497
                Article
                nanomaterials-07-00186
                10.3390/nano7070186
                5535252
                28718832
                db522157-bf2e-4a50-b6a3-f74c5b855f24
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 13 June 2017
                : 06 July 2017
                Categories
                Review

                carbon nanotubes,chiral separation,achiral separation,single-walled carbon nanotubes,multi-walled carbon nanotubes

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