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      Augmented Urinary Dilution Following Administration of Tolinase in Man

      , ,

      Nephron

      S. Karger AG

      Sulfanylurea, Diabetes, Water diuresis

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          Abstract

          Renal handling of salt and water during water diuresis was studied in the same 7 healthy subjects before and after the administration of tolinase. After tolinase there was no change in mean values of C<sub>inulin</sub>, C<sub>p-aminohipurate</sub> and calculated rate of distal sodium delivery (CH<sub>2</sub>O + C<sub>Na</sub>/100 ml glomerular filtration rate). Mean filtration fraction fell from 19.3 ± SD3.5to 16.8 ± 3.3% (p < 0.01). The mean fraction of delivered sodium reabsorbed at the diluting site (CH<sub>2</sub>O/[CH<sub>2</sub>O + C<sub>Na</sub>]) rose from 83.3 ± SD 3.6 to 88.0 ± 3.3% (p < 0.05). Mean minimal urinary osmolality fell from 85.9 ± SD 8.6 to 69.4 ± 10.3 mOsm/kg H<sub>2</sub>O (p < 0.01). Free water clearance for a given rate of urine flow was higher following tolinase than in controls. Mean rate of urinary potassium excretion fell following tolinase (p < 0.05). Maximal urinary concentration following 24 h fluid deprivation was unchanged by tolinase either in man or in the dog. Augmented tubular reabsorption of sodium at the diluting site appears to underly the lowering of minimal urinary osmolality following tolinase.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1974
          1974
          28 November 2008
          : 13
          : 2
          : 145-151
          Affiliations
          Department of Nephrology and Susan Reba Isenberg Dialysis Unit, Rambam Government Hospital, and Abba Khoushy School of Medicine, Haifa
          Article
          180387 Nephron 1974;13:145–151
          10.1159/000180387
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

          Diabetes, Water diuresis, Sulfanylurea

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