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      Method of administration determines the effect of naloxone on pain

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      Brain Research

      Elsevier BV

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          Abstract

          The opiate antagonist, naloxone, produces dose-dependent biphasic changes in clinical pain. The mechanism of the analgesia produced by low dose naloxone is unknown. To study the analgesic effect of naloxone, we have used a programmable infusion pump, which eliminates placebo-induced endorphin-mediated analgesia, to administer different doses of naloxone. We report that use of machine infusion of naloxone exclusively produces analgesia. The implications of this finding to the mechanism of naloxone-induced analgesia are discussed.

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          Author and article information

          Journal
          Brain Research
          Brain Research
          Elsevier BV
          00068993
          February 1986
          February 1986
          : 365
          : 2
          : 377-378
          Article
          10.1016/0006-8993(86)91653-7
          3948000
          © 1986

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