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      In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand.

      The American Journal of Tropical Medicine and Hygiene
      Animals, Antimalarials, pharmacology, Drug Resistance, Erythrocytes, parasitology, Humans, Inhibitory Concentration 50, Malaria, Vivax, blood, Plasmodium vivax, drug effects, isolation & purification, Statistics, Nonparametric, Thailand

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          Abstract

          The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC(50)) values were quinine = 308 ng/mL, amodiaquine =14 ng/mL, chloroquine =50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.

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