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      Myocardial Ultrasonic Tissue Characterization for Estimating Histological Abnormalities in Hypertrophic Cardiomyopathy: Comparison with Endomyocardial Biopsy Findings


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          Aims: In this study, we investigated the clinical usefulness of ultrasonic tissue characterization with integrated backscatter for the evaluation of myocardial histological abnormalities in comparison with endomyocardial biopsy findings in patients with hypertrophic cardiomyopathy. Methods: Twenty patients with hypertrophic cardiomyopathy and 20 normal subjects were enrolled in this study. We measured two parameters for the ultrasonic tissue characterization with integrated backscatter: the magnitude of the cardiac-cycle-dependent variation in integrated backscatter signals (cdv-IB) and the mean value of integrated backscatter signals calibrated by the pericardium (cal-IB). These parameters were measured at both the interventricular septum and the left ventricular posterior wall. Histological findings of right ventricular endomyocardial biopsy specimens were analyzed by computer image analyzer. Results: cdv-IB was significantly lower and cal-IB significantly higher in both the interventricular septum and the left ventricular posterior wall in patients with hypertrophic cardiomyopathy compared with normal subjects. In patients with hypertrophic cardiomyopathy, the degree of myocardial disarray, interstitial fibrosis, and nonhomogeneity of myocyte size showed positive correlations with cal-IB and negative correlations with cdv-IB. Conclusions: Ultrasonic tissue characterization with IB enables the noninvasive evaluation of myocardial histological abnormalities in patients with hypertrophic cardiomyopathy.

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          Author and article information

          S. Karger AG
          November 2001
          08 November 2001
          : 96
          : 1
          : 16-23
          aFirst Department of Internal Medicine and bDepartment of General Medicine and Clinical Investigation, Nara Medical University, Nara, and cDepartment of Pathology, National Cardiovascular Center, Osaka, Japan
          47381 Cardiology 2001;96:16–23
          © 2001 S. Karger AG, Basel

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          Page count
          Figures: 3, Tables: 1, References: 34, Pages: 8
          General Cardiology

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Integrated backscatter,Endomyocardial biopsy,Hypertrophic cardiomyopathy


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